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临床试验/NCT06611267
NCT06611267已完成不适用

En undersøgelse af Smerteoplevelsen Hos Raske forsøgsdeltagere (A Study of the Pain Experience in Healthy Participants)

University of Aarhus2 个研究点 分布在 1 个国家目标入组 64 人开始时间: 2025年2月7日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
64
试验地点
2
主要终点
Experienced pain measured on a Visual Analogue Scale (VAS) from 0-10 (from no pain to worst imaginable pain) without cream compared to experienced pain measured on a Visual Analogue Scale (VAS) from 0-10 (from no pain to worst imaginable pain) with cream

研究概览

简要总结

The experiment aims to investigate the experience of pain in healthy adults and includes a total of 60 participants. Pain is a subjective experience that has a complicated neurological and psychological basis. Around 20% of the Danish population suffers from persistent pain, which has both personal and societal consequences. Personal consequences include, among others, reduced quality of life, loss of social life and risk of anxiety and depression. However, more knowledge is needed about which mechanisms are involved in the experience of pain, so that the treatment of patients with pain can be improved.

In the experiment, healthy participants will be inflicted with a tolerable pain on their forearm using a thermode. The application of heat causes pain for a short, limited period, but it is tolerable and without risks. During the experiment, the participants will be exposed to heat several times, with and without a cream on their forearm. It is a cream that has previously proved to have pain-relieving effects on participants in similar experiments. Participants will be asked about how they experience the intensity of the pain on a scale of 1-10 (0 = no pain and 10 = worst imaginable pain), and what they expect the pain intensity will be, also on a 1-10 scale. The participants are allowed to pause or stop the experiment anytime.

The experiment contributes to insights into pain and the mechanisms involved. This knowledge can in the future contribute with knowledge to improve the treatment of patients with pain. For the individual participant, the trial will contribute with knowledge about how they experience and assess pain themselves.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Factorial
主要目的
Basic Science
盲法
Single (Participant)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Normal health, i.e. no known acute or chronic illness
  • Fluid in Danish

排除标准

  • Chronic pain condition
  • Other medical or psychiatric disorder
  • Use of antidepressants
  • Daily use of painkillers
  • Use of pain medication 24 hours prior to testing
  • Drug abuse
  • Pregnancy
  • Studying or with completed education in psychology or journalism

结局指标

主要结局

Experienced pain measured on a Visual Analogue Scale (VAS) from 0-10 (from no pain to worst imaginable pain) without cream compared to experienced pain measured on a Visual Analogue Scale (VAS) from 0-10 (from no pain to worst imaginable pain) with cream

时间窗: From beginning to end of experiment, approx. 45 minutes

次要结局

  • The effect of assessing expected pain intensity measured on a Visual Analogue Scale (VAS) from 0-10 (from no expected pain to worst imaginable expected pain)(From beginning to end of experiment, approx. 45 minutes)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (2)

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Experiences of Pain in Healthy Adults | 临床试验