Effect of renal sympathetic denervation on renal and overall sympathetic output in patients with therapy resistant hypertensio

Completed

Conditions: Therapy resistant hypertension
renal sympathetic denervation
10018424
10057166

Registration Number: NL-OMON37991

Lead Sponsor: Academisch Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

Patients aged 40-70 years receiving RSD for therapy resistant hypertension, defined as daytime ABPM*150/100 mmHg despite the use of 3 or more anti-hypertensive drugs including or with intolerance to a diuretic.;No evidence of secondary hypertension (renal artery stenosis, pheochromocytoma, primary aldosteronism and hyper- or hypothyroidism have to be excluded prior to the intervention). ;Normal renal anatomy, single renal artery bilaterally.;Able to provide informed consent. ;Willingness to participate.

Exclusion Criteria

Renal insufficiency (eGFR<45 ml/min) or proteinuria>1 gram/24 hrs.;Pacemaker or ICD device;Atrial fibrillation;Diabetes Mellitus type 1;Unstable weight 3 months prior to inclusion;Pregnancy ;Treatment of DM type 2 with insulin, PPARγ-agonists or SU-dervatives (for clamp experiment only)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary objectives:<br /><br>To determine predictors of the BP lowering response of RSD by evaluation of:<br /><br>1. Assessment of sympathetic tone by beat-to-beat analysis<br /><br>2. Assessment of the effectiveness of RSD by renal MIBG-uptake<br /><br>post-intervention<br /><br>3. Assesment of medication adherence before and after RSD.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary objectives:<br /><br>To assess the auxiliary effects of RSD on:<br /><br>1. Insulin sensitivity<br /><br>2. Low grade inflammation<br /><br>3. Central haemodynamics.</p><br>