NL-OMON37991
Completed
Not Applicable
Effect of renal sympathetic denervation on renal and overall sympathetic output in patients with therapy resistant hypertension - Effect of renal sympathetic denervation on sympathetic nervous activity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Therapy resistant hypertension
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 30
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients aged 40\-70 years receiving RSD for therapy resistant hypertension, defined as daytime ABPM\*150/100 mmHg despite the use of 3 or more anti\-hypertensive drugs including or with intolerance to a diuretic.;No evidence of secondary hypertension (renal artery stenosis, pheochromocytoma, primary aldosteronism and hyper\- or hypothyroidism have to be excluded prior to the intervention). ;Normal renal anatomy, single renal artery bilaterally.;Able to provide informed consent. ;Willingness to participate.
Exclusion Criteria
- •Renal insufficiency (eGFR\<45 ml/min) or proteinuria\>1 gram/24 hrs.;Pacemaker or ICD device;Atrial fibrillation;Diabetes Mellitus type 1;Unstable weight 3 months prior to inclusion;Pregnancy ;Treatment of DM type 2 with insulin, PPARγ\-agonists or SU\-dervatives (for clamp experiment only)
Outcomes
Primary Outcomes
Not specified
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