TSPO PET tracing In patients with and without Cognitive impairment in the long-term after AneurySmal Subarachnoid haemorrhage

Completed

• Conditions: aneurysmal subarachnoid hemorrhage (aSAH); bleeding between the coverings of the brain due to an aneurysm; 10007963; 10009841; 10002363

• Registration Number: NL-OMON55660
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 36

Inclusion Criteria

Subjects (n = 14) with aSAH >3 years ago and cognitive impairment
- Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as
o Blood on initial non-contrast CT or bilirubin in cerebrospinal fluid (CSF)
o A proven aneurysm, demonstrated by computed tomography angiography (CTA),
digital subtraction angiography (DSA) or magnetic resonance angiography (MRA)
- Genotyping of rs6971 must show that patient is a high affinity binder
- Functional independence (defined as modified rankin scale (mRS) or 0-2)
o mRS (Dutch) table can be found in Appendix 1
- Patient must have been at least 18 years of age at time of visit to the
outpatient clinic.
- Neuropsychological evaluation shows cognitive impairment.

Subjects (n = 14) with aSAH >3 years ago and no cognitive impairment
- Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as
o Blood on initial non-contrast CT or bilirubin in CSF
o A proven aneurysm, demonstrated by CTA, DSA or MRA
- Genotyping of rs6971 must show that patient is a high affinity binder
- Functional independence (defined as mRS or 0-2)
o mRS (Dutch) table can be found in Appendix 1
- Patient must have been at least 18 years of age at time of visit to the
outpatient clinic.
- Neuropsychological evaluation shows no cognitive impairment.

Controls (n = 8) with unruptured aneurysms
- Admitted to the UMCU with an unruptured aneurysm, defined as
o A proven aneurysm, demonstrated by CTA, DSA or MRA
- Genotyping of rs6971 must show that patient is a high affinity binder
- Functional independence (defined as mRS of 0-2)
- Patient must have been at least 18 years of age at time of visit to the
outpatient clinic.
- Neuropsychological evaluation shows no cognitive impairment.

Exclusion Criteria

- Contra-indication for PET-MRI scanning (such as severe lower back pain or
claustrophobia)
- Pregnancy
- Exposure to ionic radiation (clinical or experimental) in the past year

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified