NL-OMON55660
Completed
Not Applicable
TSPO PET tracing In patients with and without Cognitive impairment in the long-term after AneurySmal Subarachnoid haemorrhage - PICASSO
niversitair Medisch Centrum Utrecht0 sites36 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- aneurysmal subarachnoid hemorrhage (aSAH)
- Sponsor
- niversitair Medisch Centrum Utrecht
- Enrollment
- 36
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Subjects (n \= 14\) with aSAH \>3 years ago and cognitive impairment
- •\- Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as
- •o Blood on initial non\-contrast CT or bilirubin in cerebrospinal fluid (CSF)
- •o A proven aneurysm, demonstrated by computed tomography angiography (CTA),
- •digital subtraction angiography (DSA) or magnetic resonance angiography (MRA)
- •\- Genotyping of rs6971 must show that patient is a high affinity binder
- •\- Functional independence (defined as modified rankin scale (mRS) or 0\-2\)
- •o mRS (Dutch) table can be found in Appendix 1
- •\- Patient must have been at least 18 years of age at time of visit to the
- •outpatient clinic.
Exclusion Criteria
- •\- Contra\-indication for PET\-MRI scanning (such as severe lower back pain or
- •claustrophobia)
- •\- Pregnancy
- •\- Exposure to ionic radiation (clinical or experimental) in the past year
Outcomes
Primary Outcomes
Not specified