NL-OMON55660已完成不适用
TSPO PET tracing In patients with and without Cognitive impairment in the long-term after AneurySmal Subarachnoid haemorrhage - PICASSO
niversitair Medisch Centrum Utrecht0 个研究点目标入组 36 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 36
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Subjects (n = 14) with aSAH >3 years ago and cognitive impairment
- •- Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as
- •o Blood on initial non-contrast CT or bilirubin in cerebrospinal fluid (CSF)
- •o A proven aneurysm, demonstrated by computed tomography angiography (CTA),
- •digital subtraction angiography (DSA) or magnetic resonance angiography (MRA)
- •- Genotyping of rs6971 must show that patient is a high affinity binder
- •- Functional independence (defined as modified rankin scale (mRS) or 0-2)
- •o mRS (Dutch) table can be found in Appendix 1
- •- Patient must have been at least 18 years of age at time of visit to the
- •outpatient clinic.
- •- Neuropsychological evaluation shows cognitive impairment.
- •Subjects (n = 14) with aSAH >3 years ago and no cognitive impairment
- •- Admitted to the UMCU with aneurysmal SAH at least 3 years ago, defined as
- •o Blood on initial non-contrast CT or bilirubin in CSF
- •o A proven aneurysm, demonstrated by CTA, DSA or MRA
- •- Genotyping of rs6971 must show that patient is a high affinity binder
- •- Functional independence (defined as mRS or 0-2)
- •o mRS (Dutch) table can be found in Appendix 1
- •- Patient must have been at least 18 years of age at time of visit to the
- •outpatient clinic.
- •- Neuropsychological evaluation shows no cognitive impairment.
- •Controls (n = 8) with unruptured aneurysms
- •- Admitted to the UMCU with an unruptured aneurysm, defined as
- •o A proven aneurysm, demonstrated by CTA, DSA or MRA
- •- Genotyping of rs6971 must show that patient is a high affinity binder
- •- Functional independence (defined as mRS of 0-2)
- •- Patient must have been at least 18 years of age at time of visit to the
- •outpatient clinic.
- •- Neuropsychological evaluation shows no cognitive impairment.
排除标准
- •- Contra-indication for PET-MRI scanning (such as severe lower back pain or
- •claustrophobia)
- •- Pregnancy
- •- Exposure to ionic radiation (clinical or experimental) in the past year
研究者
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