C1q/TNF-related Proteins in Coronary Artery Disease

Terminated

• Conditions: Coronary Artery Disease (CAD)

• Registration Number: NCT02083146
• Lead Sponsor: Korea University

Brief Summary

Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.

Detailed Description

Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.

Study Timeline

• Study Start: 2011-03
• Primary Completion: 2012-12
• Study First Submitted: 2014-03-07
• Study First Submitted QC: 2014-03-07
• Study First Posted: 2014-03-11
• Study Completion: 2016-02
• Status Verified: 2018-03
• Last Update Submitted: 2018-03-17
• Last Update Posted: 2018-03-20

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 362

Inclusion Criteria

• 20<age<80
• History of stable angina, unstable angina, or acute myocardial infarction

Exclusion Criteria

• a history of diabetes
• stage 2 hypertension
• malignancy
• severe renal or hepatic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD	at enrollment	compare serum concentration of CTRP-1,3 or 9 between CAD patients and normal group

Secondary Outcome Measures

Name	Time	Method
The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles	at enrollment	find the correlation of CTRPs and adiponection with cardiometabolic risk

Trial Locations

Locations (1)

Korea Univ. Guro Hospital; 🇰🇷 Seoul, Korea, Republic of