C1q/TNF-related Proteins in Coronary Artery Disease
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 362
- 试验地点
- 1
- 主要终点
- serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD
研究概览
简要总结
Now, adipose tissue is established as an active endocrine organ that controls systemic energy homeostasis by secretion of adipokines. Recently, members of the C1q/tumor necrosis factor-related protein (CTRP) family have been reported to share structural homology with adiponectin. To date, 15 CTRP family members have been found that might play major roles in metabolism and inflammation. The investigators tried to clarify the relationship between CTRP family and coronary artery disease (CAD) in Korean men and women.
详细描述
Adipose tissue secretes various kinds of bioactive molecules termed adipokines which contribute to the development of obesity-related disorders including cardiovascular disease (CVD). Adiponectin is the insulin-sensitizing adipokine with anti-inflammatory and anti-atherogenic properties. Hypoadiponectinemia has been associated with an increased risk of coronary artery disease (CAD) in several though not all studies. Recently, a new family of secreted proteins, C1q/TNF-related protein (CTRP), was cloned on the basis of sequence homology with adiponectin. This family of adiponectin paralogs might have pivotal implications in energy homeostasis and obesity-related inflammation. Each CTRP family member has its own unique tissue expression profile and function in regulating glucose and/or fat metabolism. In the present study, we evaluated the role of CTRP in patients with CAD and investigated whether CTRP family is significantly associated with CAD prevalence after adjustment for well-known CAD risk factors.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •20<age<80
- •History of stable angina, unstable angina, or acute myocardial infarction
排除标准
- •a history of diabetes
- •stage 2 hypertension
- •malignancy
- •severe renal or hepatic disease
结局指标
主要结局
serum concentration of CTRP-1,3, or 9 in the subjects with/without CAD
时间窗: at enrollment
compare serum concentration of CTRP-1,3 or 9 between CAD patients and normal group
次要结局
- The relationships of serum CTRPs/adiponectin levels with cardiometabolic risk profiles(at enrollment)