EUCTR2015-004433-26-GB进行中（未招募）1 期
Zoledronic acid in the management of malignant pleural mesothelioma - a feasibility study - ZOL-A trial
orth Bristol NHS Trust0 个研究点目标入组 22 人开始时间: 2016年3月17日最近更新:
适应症
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 22
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
入选标准
- •-Histo-cytologically confirmed diagnosis of MPM
- •-WHO performance status 0-1
- •-Eligible for first line chemotherapy treatment
- •-Measurable disease on CT as per modified RECIST criteria (tumour thickness >5mm)
- •-Ability to give informed consent
- •Are the trial subjects under 18? no
- •Number of subjects for this age range: 0
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 25
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 45
排除标准
- •Not fit for chemotherapy due to performance status or other comorbidities
- •Previous chemotherapy for MPM
- •IV bisphosphonates in the 3 months preceding randomisation
- •Significant renal disease (eGFR < 30ml/min in the last 4 weeks)
- •Hypocalcaemia (current hypocalcaemia on treatment, evidence of hypocalcaemia on most recent blood tests – should be within the last 6 weeks)
- •Known allergy to bisphosphonates or excipients of its preparation
- •Severe untreated dental caries
- •Concomitant participation in another drug trial for mesothelioma
- •Allergy to 18-Fluodeoxyglucose used for the PET scan
- •Women of child bearing potential (defined as fertile, or following menarche and until becoming post-menopausal unless permanently sterile)
研究者
相似试验
进行中（未招募）
1 期
A pilot study to investigate Zoledronic acid as a add on treatment in neovascular Age-related Macular Degeneratioeovascular Age-related Macular DegenerationMedDRA version: 20.0Level: PTClassification code 10071129Term: Neovascular age-related macular degenerationSystem Organ Class: 10015919 - Eye disordersEUCTR2019-001492-37-NOOslo University Hospital40
尚未招募
不适用
Clinical study of MP plus zoledronic acid therapy in newly diagnosed multiple myeloma excluding stem cell transplantation patientsMultiple MyelomaJPRN-UMIN000002158Division of clinial oncology and hematology, Jikei University School of Medicine5
已完成
2 期
Efficacy and Safety of Zoledronic acid on urological cancer patients with bone metastasis: a phase II clinical study.rological Cancer with bone metastasis (Hormone resistant prostate cancer, Kidney cancer, urothelial cancer, kidney pelvis and ureteral cancer)JPRN-UMIN000002291Department of Urology, Graduate School of Medical Sciences, Kyushu University100
招募中
不适用
Study of therapy with zoledronic acid in prostate cancer patients with bone metastases.Prostate CancerJPRN-UMIN000011442Osaka University Graduate School of Medicine,Department of Organ Specific Regulation (Urology)200
终止
3 期
Safety/Efficacy of Intravenous Zoledronic Acid When Added to Standard Therapies in Patients With Breast Cancer and Metastatic Bone LesionsBreast Cancer With Bone MetastasisNCT00372710Novartis30