The Safety and Efficacy of Panobinostat for Eradicating The Latent Reservoir of HIV-infection (CLEAR) Study

• Conditions: Human Immunodeficiency Virus (HIV) Infection; MedDRA version: 14.1Level: LLTClassification code 10020172Term: HIV infection NOSSystem Organ Class: 10021881 - Infections and infestations; MedDRA version: 14.1Level: LLTClassification code 10020192Term: HIV-1System Organ Class: 10021881 - Infections and infestations; Therapeutic area: Diseases [C] - Virus Diseases [C02]

• Registration Number: EUCTR2012-000240-94-DK
• Lead Sponsor: Aarhus University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2012-04-23
• Last Update Posted: 7 October 2014

Recruitment & Eligibility

• Status: ot Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

•Documented HIV-1 infection
•Age >18 years
•HIV-1 plasma RNA <50 copies/ml for at least 2 years with at least 2 viral load measures per year. Episodes of a single HIV plasma RNA 50-199 copies/ml will not exclude participation if the subsequent HIV plasma RNA was <50 copies/ml
•Receiving HAART, defined as at least 2 nucleoside/nucleotide reverse transcriptase inhibitors plus a non-nucleoside reverse transcriptase inhibitor, integrase inhibitor, or a protease inhibitor
•CD4+ T-cell count >500/mm3 on minimum 2 occasions in the last 12 months prior to study entry
•Able to give informed consent

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range 16
F.1.3 Elderly (>=65 years)
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

•Any significant acute medical illness in the past 8 weeks
•Any evidence of an active AIDS-defining opportunistic infection
•Current or recent gastrointestinal disease that may impact the absorption of the investigational drug
•Any gastrointestinal surgery that could impact upon the absorption of the investigational drug
•Active alcohol or substance use that, in the Investigator's opinion, will prevent adequate compliance with study therapy
•Patient has the following laboratory values within 3 weeks before starting the investigational drug (lab tests may be repeated, as clinically indicated, to obtain acceptable values before failure at screening is concluded but supportive therapies are not to be administered within the week prior to screening tests for ANC or platelet count)
oHepatic transaminases (AST or ALT) =3 x upper limit of normal (ULN)
oSerum total bilirubin =1.5 ULN
oSerum creatinine levels =1.5 x ULN, or calculated creatinine clearance =60 ml/min
oPlatelet count =100 x109/L
oAbsolute neutrophil count =1.5x109/L
oSerum potassium, magnesium, phosphorus outside normal limits
oTotal calcium (corrected for serum albumin) or ionized calcium =lower normal limits
•Hepatitis B or C infection as indicated by the presence of Hepatitis B surface antigen (HBsAg) or hepatitis C virus RNA (HCV-RNA) in blood
•A personal history of clinically significant cardiac disease, symptomatic or asymptomatic arrhythmias, syncopal episodes, or additional risk factors for torsades de pointes (e.g. heart failure)
•History of malignancy or transplantation, including skin cancers or Kaposi sarcoma
•History of diabetes mellitus
•Use of a protease inhibitor
•Receipt of immunomodulating agents, immunization or systemic chemotherapeutic agents within 28 days prior to study entry
•Use of an agent definitely or possibly associated with effects on QT intervals within 2 weeks of screening
•ECG at screening that shows QTc >450 msec when calculated using the Fridericia formula from either lead V3 or V4
•Known resistance to >2 classes of ART
•Has known hypersensitivity to the components of panobinostat or its analogues
•Current use of sodium valproate or other HDAC inhibitor
•Women who are pregnant or breastfeeding, or with a positive pregnancy test during screening or Women of Child Bearing Potential (WOCBP) who are unwilling or unable to use an acceptable method of contraception (according to the Danish Medicines Agency guidelines) to avoid pregnancy for the entire study period and for at least 4 weeks before and 4 weeks after study treatment
•Males or females who are unwilling or unable to use barrier contraception during sexual intercourse for the entire study period, including at least 4 weeks before, 4 weeks after study treatment, and when plasma HIV-RNA is detectable using standard assays

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified