Efficacy and Safety of Tirofiban Versus Placebo After Successful Reperfusion With Endovascular Thrombectomy in Acute Ischemic Stroke Patients With Anterior Circulation Large Vessel Occlusion: a Multicenter, Double-Blind, Randomized Clinical Trial
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 712
- 主要终点
- Functional independence
研究概览
简要总结
Up to 50% of acute ischemic stroke patients with large vessel occlusion failed to achieve functional independence even after successful reperfusion therapy, a phenomenon that is referred to as "futile recanalization". The mechanism of futile recanalization is complex, and some studies have shown that it may be related to factors such as tissue no reflow, reocclusion, poor status of collateral circulation, hemorrhagic transformation, impaired cerebrovascular autonomic regulation, and low perfusion volume. Several studies suggested that maximizing the improvement of cerebral reperfusion is still the primary goal of acute large vessel occlusive stroke. Structural and functional alterations in the microvascular system may be a major obstacle to reperfusion. In animal models of cerebral ischemia, downstream microvascular thrombosis may occur in the early stage of cerebral ischemia and before vascular recanalization, which is the main factor leading to incomplete reperfusion and affecting the efficacy of endovascular thrombectomy.
Mechanical thrombectomy mainly addressed the occluded large arteries, and does not consider the distal arteries. However, the recanalization of occluded large arteries does not necessarily translate into successful reperfusion of the ischemic tissue supplied by the distal capillaries. Even with complete recanalization, impaired microcirculatory reperfusion may lead to poor clinical outcomes. Therefore, we speculate that at the end of endovascular thrombectomy, microthrombi remain present in the microcirculation of brain tissue in patients with complete or near-complete cerebral angiography, and that microthrombi is more likely to be dissolved than thrombus more proximal to the heart. Therefore, intra-arterial administration of pharmaceutical, such as tirofiban, may be the only possible option to ensure complete reperfusion of ischemic tissue. Tirofiban is a platelet glycoprotein IIb/IIIa receptor antagonist, which has been widely used in acute coronary syndrome, and its role in acute ischemic stroke has attracted more and more attention from stroke experts. Previous studies have suggested that tirofiban can further increase the incidence of successful recanalization, while reducing the reocclusion rate.
Whether early administration of intraarterial and intravenous tirofiban can further improve the clinical outcomes of patients with large vessel occlusive stroke after successful mechanical thrombectomy remains unclear.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical inclusion criteria
- •Aged 18 years or older;
- •Acute ischemic stroke within 24 hours from last known well to randomization;
- •NIHSS score ≥6 and <30 points at baseline;
- •Written informed consent is obtained from patients and/or their legal representatives.
- •Imaging inclusion criteria
- •CTA/MRA/DSA showed occlusion of the internal carotid artery, middle cerebral artery M1 or M2 segment;
- •For patients within 6 hours from last known well to randomization, ASPECTS 3-10 or infarct volume ≤100ml; 6-24 hours, ASPECTS 6-10 or infarct volume ≤70ml or DWI-FLAIR mismatch;
- •Treated with endovascular thrombectomy and achieved successful reperfusion (defined as eTICI grade 2b50 or higher).
排除标准
- •Cardiogenic embolism;
- •Patient receive tirofiban for angioplasty/stenting prior to randomization;
- •Intracranial hemorrhage confirmed by flat panel CT on angiography machine prior to randomization;
- •Patients who are on prior anticoagulant therapy, e.g. for deep venous thrombosis or pulmonary embolism or mechanical heart valve;
- •Routine blood test platelet count less than 100×10⁹/L;
- •Renal insufficiency, glomerular filtration rate < 60 mL/min;
- •Pregnant or lactating women;
- •Allergy to tirofiban, contrast agent, nickel, titanium or its alloys;
- •History of neurological or psychiatric illness that precludes the assessment of neurological function;
- •History of bleeding disorder, severe heart, liver or kidney disease, or sepsis;
- •Any terminal illness with life expectancy less than 6 months;
- •Participating in other treatment clinical trials.
研究组 & 干预措施
Tirofiban
Intraarterial and intravenous tirofiban
干预措施: Intraarterial and intravenous tirofiban (Drug)
Placebo
Intraarterial and intravenous placebo
干预措施: Intraarterial and intravenous placebo (Drug)
结局指标
主要结局
Functional independence
时间窗: 90 days post-randomization
modified Rankin scale score of 0 to 2. (The modified Rankin scale scores range from 0 to 6, with 0 indicating no disability, 1 no clinically significant disability, 2 slight disability, 3 moderate disability but able to walk unassisted, 4 moderately severe disability, 5 severe disability, and 6 death)
次要结局
- Mortality(90 days post-randomization)
- Level of disability(90 days post-randomization)
- Excellent outcome(90 days post-randomization)
- Independent ambulation(90 days post-randomization)
- Radiologic intracranial hemorrhage rate(within 48 hours post-randomization)
- Long-term of disability level(1 year post-randomization)
- Incidence of non-hemorrhagic serious adverse events(90 days post-randomization)
- Recanalization on follow-up CTA or MRA(within 48 hours post-randomization)
- Health-related quality of life(90 days post-randomization)
- Health-related quality of life (long-term)(1 year post-randomization)
- Early neurologic improvement(within 48 hours post-randomization)
- Incidence of symptomatic intracranial hemorrhage (SICH)(within 48 hours post-randomization)
研究者
Zhongming Qiu
Professor
Xinqiao Hospital of Chongqing