Skip to main content
Clinical Trials/NCT05871619
NCT05871619
Completed
Not Applicable

Clinical Efficacy of Combined Application of Diode Laser and Different Remineralizing Agents on Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions

Al-Azhar University1 site in 1 country45 target enrollmentMay 5, 2022

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
White Spot Lesion of Tooth
Sponsor
Al-Azhar University
Enrollment
45
Locations
1
Primary Endpoint
Spectrophotometric color assessment:
Status
Completed
Last Updated
2 years ago

Overview

Brief Summary

Dental caries is a very common condition, and although it has become less common, it still represents a serious public health risk. Caries symptoms range from the earliest molecular alterations in the tooth's apatite crystals to an apparent white spot lesion (WSL) or eventual cavitation. The white spot lesion looks chalky because minerals are being lost from both the surface and the underside of the enamel. A relatively simple and noninvasive caries preventive regimen in treating white spot lesions with low-level laser irradiation, either alone or with topical fluoride treatment. This treatment results in reduced enamel solubility and dissolution.

Detailed Description

The study was reviewed and approved by the "Ethical research committee "of the Faculty of Dental Medicine for Girls; at Al-Azhar University, Cairo, Egypt. This study was conducted on 90 teeth with white spot lesions (WSLs) detected clinically on the buccal surface of teeth. The patients with WSLs were selected randomly from the operative dentistry clinic at the Faculty of Dentistry, Girl's Branch, Al-Azhar University After examination, the teeth will be assigned into six groups of 15 teeth with white spot lesions each according to the remineralizing material used: * The first group (A1B1): The teeth with WSL will be treated with nano-hydroxyapatite +fluoride with laser application. * The second group (A1B2): The contralateral teeth will be treated with nano-hydroxyapatite +fluoride without laser application. * The third group (A2B1): The teeth with WSL will be treated with nano-hydroxyapatite + xylitol with laser application. * The fourth group (A2B2): The contralateral teeth will be treated with nano hydroxyapatite+ xylitol without laser application. * The fifth group (A3B1): The teeth with WSL will be treated with 5% sodium fluoride varnish with laser application. * The sixth group (A3B2): The contralateral teeth will be treated with 5% sodium fluoride without laser application.

Registry
clinicaltrials.gov
Start Date
May 5, 2022
End Date
April 20, 2023
Last Updated
2 years ago
Study Type
Interventional
Study Design
Parallel
Sex
Female

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Amani abdullah Omar bin shahna

operative clinic

Al-Azhar University

Eligibility Criteria

Inclusion Criteria

  • The patients should be 13-40 years old.
  • Patients should have good oral hygiene.
  • The patients with good general health and no systemic disease.

Exclusion Criteria

  • - Presence of enamel hypoplasia or dental fluorosis.
  • Presence of carious cavity.
  • Patients who have a significant medical history,
  • Patients who have evidence of reduced salivary flow or significant tooth wear.

Outcomes

Primary Outcomes

Spectrophotometric color assessment:

Time Frame: from base line (application of materials) to one month

The Vita Easy shade spectrophotometer (Vita Zahnfabrik, Bad Säckingen, Germany) was employed for the color assessment WSLs

Secondary Outcomes

  • surface area measurement(from base line (application of materials) to one month)

Study Sites (1)

Loading locations...

Similar Trials