Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions

Not Applicable

Completed

• Conditions: White Spot Lesion of Tooth

• Registration Number: NCT05871619
• Lead Sponsor: Al-Azhar University

Brief Summary

Dental caries is a very common condition, and although it has become less common, it still represents a serious public health risk. Caries symptoms range from the earliest molecular alterations in the tooth's apatite crystals to an apparent white spot lesion (WSL) or eventual cavitation. The white spot lesion looks chalky because minerals are being lost from both the surface and the underside of the enamel. A relatively simple and noninvasive caries preventive regimen in treating white spot lesions with low-level laser irradiation, either alone or with topical fluoride treatment. This treatment results in reduced enamel solubility and dissolution.

Detailed Description

The study was reviewed and approved by the "Ethical research committee "of the Faculty of Dental Medicine for Girls; at Al-Azhar University, Cairo, Egypt. This study was conducted on 90 teeth with white spot lesions (WSLs) detected clinically on the buccal surface of teeth. The patients with WSLs were selected randomly from the operative dentistry clinic at the Faculty of Dentistry, Girl's Branch, Al-Azhar University

After examination, the teeth will be assigned into six groups of 15 teeth with white spot lesions each according to the remineralizing material used:

* The first group (A1B1): The teeth with WSL will be treated with nano-hydroxyapatite +fluoride with laser application.

* The second group (A1B2): The contralateral teeth will be treated with nano-hydroxyapatite +fluoride without laser application.

* The third group (A2B1): The teeth with WSL will be treated with nano-hydroxyapatite + xylitol with laser application.

* The fourth group (A2B2): The contralateral teeth will be treated with nano hydroxyapatite+ xylitol without laser application.

* The fifth group (A3B1): The teeth with WSL will be treated with 5% sodium fluoride varnish with laser application.

* The sixth group (A3B2): The contralateral teeth will be treated with 5% sodium fluoride without laser application.

Study Timeline

• Study Start: 2022-05-05
• Primary Completion: 2022-06-05
• Study Completion: 2023-04-20
• Status Verified: 2023-05
• Study First Submitted: 2023-05-13
• Study First Submitted QC: 2023-05-13
• Study First Posted: 2023-05-23
• Last Update Submitted: 2023-05-23
• Last Update Posted: 2023-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 45

Inclusion Criteria

• The patients should be 13-40 years old.
• Patients should have good oral hygiene.
• The patients with good general health and no systemic disease.

Exclusion Criteria

• • Presence of enamel hypoplasia or dental fluorosis.
• Presence of carious cavity.
• Patients who have a significant medical history,
• Patients who have evidence of reduced salivary flow or significant tooth wear.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Spectrophotometric color assessment:	from base line (application of materials) to one month	The Vita Easy shade spectrophotometer (Vita Zahnfabrik, Bad Säckingen, Germany) was employed for the color assessment WSLs

Secondary Outcome Measures

Name	Time	Method
surface area measurement	from base line (application of materials) to one month	after the finalization of the remineralization protocol, another radiographic examination was undertaken. Bitewing radiographs of the lesions were taken using the same X-ray unit, film holders for bite recording and vertical angulations for standardizing the geometric projection of the X-ray beam by digital subtraction radiograph.

Trial Locations

Locations (1)

Al-Azhar University; 🇪🇬 El Cairo, Egypt