Phase I/II Trial of Vaccine Therapy With Tumor Stem Cell Derived mRNA- Transfected Dendritic Cells in Patients Receiving Standard Therapy for Glioblastoma

Oslo University Hospital0 sites20 target enrollmentJanuary 2009

ConditionsGlioblastoma Brain Tumor

Overview

Phase: Phase 1
Intervention: Not specified
Conditions: Glioblastoma
Sponsor: Oslo University Hospital
Enrollment: 20
Primary Endpoint: Adverse events
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Similar Trials

Overview

Brief Summary

The study induces an immune response towards the stem-cell like part of glioblastomas in combination with standard therapy. The aim is to define and characterize the feasibility, potential adverse effects of such therapy and measure time to progression and survival.

Registry

clinicaltrials.gov

Start Date

January 2009

End Date

February 2013

Last Updated

10 years ago

Study Type

Interventional

Study Design

Single Group

Sex

All

Investigators

Sponsor

Oslo University Hospital

Responsible Party

Principal Investigator

Steinar Aamdal

Oslo University Hospital

Eligibility Criteria

Inclusion Criteria

•Accessible volume and quality of tumor tissue for vaccine production
•MRI after surgery with minimal tumor remnant.
•Between 18 and 70 years of age.
•Must have histologically confirmed glioma grade IV, and a candidate for combined radiation therapy and chemotherapy ("Stupps regimen").
•Must be ambulatory with a ECOG performance status 0 or
•A minimum 4 weeks must have elapsed between the end of glucocorticoid treatment and beginning of vaccination.
•Signed informed consent and expected cooperation of the patients for the treatment and follow up must be obtained and documented.

Exclusion Criteria

•Tumor in a localization where a modest increase in size due to reactive oedema may have a large impact on patients neurological condition.
•Large tumor remnant after surgery.
•History of prior malignancy other than glioma, with the exception of curatively treated basal cell or squamous cell carcinoma of the skin and ca. cervicis stage IB.
•Chronic active infection requiring antibiotic therapy.
•Significant cardiac or other medical illness that would limit activity or survival, such as severe congestive heart failure, unstable angina, or serious cardiac arrhythmia.
•Prior splenectomy.
•Glucocorticoid treatment not possible to terminate due to autoimmune disease or increased intracranial pressure.
•Adverse reactions to vaccines such as asthma, anaphylaxis or other serious reactions.
•History of immunodeficiency or autoimmune disease such as rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis- dermatomyositis, juvenile onset insulin dependent diabetes, or a vasculitic syndrome.
•Chemotherapy or other potentially immune-suppressive therapy that has been administered within 4 weeks prior to vaccination.