Etiological Diagnosis of Urinary Stone in Chinese Children

• Conditions: Urinary Stone

• Registration Number: NCT02949323
• Lead Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine

Brief Summary

The incidence of nephrolithiasis in children has been reported to increase by approximately 6-10% annually, and the incidence is currently 50 per 100,000 children with high recurrent rate. Investigators aimed to determine the metabolic risk factors in Chinese children through metabolic evaluation.

In order to identify diagnostic criteria of hypocitraturia and hyperoxaluria in western country wether adapt to Chinese children, investigators aim to determine normal urine levels of oxalate and citrate in children without kidney stone.

Detailed Description

Investigators aimed to determine the metabolic risk factors in 200 Chinese children with urinary stones through metabolic evaluation.

In order to identify diagnostic criteria of hypocitraturia and hyperoxaluria in western country wether adapt to Chinese children, investigators aim to determine normal urine levels of oxalate and citrate in children without kidney stone.

Study Timeline

• Status Verified: 2016-10
• Study First Submitted: 2016-10-26
• Study First Submitted QC: 2016-10-28
• Last Update Submitted: 2016-10-28
• Study First Posted: 2016-10-31
• Last Update Posted: 2016-10-31
• Study Start: 2016-11
• Primary Completion: 2019-12
• Study Completion: 2019-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 200

Inclusion Criteria

• Children with urinary stones

Exclusion Criteria

• Anatomic urinary system abnormality, vesicoureteral reflux, urinary tract infection (temperature >38°C and/or positive urine culture), solitary kidney, and renal insufficiency

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Urinary oxalate;	urine collected in 24 hours

Secondary Outcome Measures

Name	Time	Method
Urinary citrate;	urine collected in 24 hours
Urinary calcium	urine collected in 24 hours

Trial Locations

Locations (1)

Department of Pediatric urology,Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine; 🇨🇳 Shanghai, China