Study of Inflammatory Role of Epstein-Barr Virus (EBV) in Atrophic and Erosive Forms of Oral Lichen Planus
Not Applicable
Completed
- Conditions
- Lichen Planus, Oral
- Interventions
- Biological: buccal cavity sample
- Registration Number
- NCT02276573
- Lead Sponsor
- Centre Hospitalier Universitaire de Nice
- Brief Summary
Oral lichen planus (OLP) is a chronic inflammatory and relapsing. The average prevalence is 1 to 4%. The clinics forms are many and symptoms are varied. The erosive form, painful and debilitating is characterized by erosive areas, ulcerated on an erythematous base with or without a keratinocyte lichenien network.
The literature data moving towards an autoimmune origin, but the pathophysiological mechanisms of OLP remain unknown.
This project represents the first part of a comprehensive project to examine the oral pathogenesis of different viruses (Herpes and papillomavirus HPV) and centered on Epstein-Barr Virus (EBV).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 13
Inclusion Criteria
- Patient ≥ 18 years
- Clinical and/or histological diagnosis of erosive or atrophic OLP
- No signs of severe dysplasia at the sampling
Exclusion Criteria
o immunosuppressive or anti-inflammatory therapies at the inclusion
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Oral lichen planus disease buccal cavity sample buccal cavity sample
- Primary Outcome Measures
Name Time Method Measure of level of EBV nucleic acids day 1
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hôpital saint Roch
🇫🇷Nice, France