Phase 2 Study of ABT-869 in Combination With mFOLFOX6 Versus Bevacizumab in Combination With mFOLFOX6 to Treat Advanced Colorectal Cancer
- Conditions
- Advanced Colorectal CancerAdenocarcinoma of the ColonAdenocarcinoma of the Rectum
- Interventions
- Registration Number
- NCT00707889
- Lead Sponsor
- AbbVie (prior sponsor, Abbott)
- Brief Summary
To determine the effect of ABT-869 plus mFOLFOX6 compared to bevacizumab plus mFOLFOX6 on disease progression in advanced colorectal cancer.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 159
Subject must be >/= 18 years of age. Subject (male or female) must be diagnosed with adenocarcinoma of the colon or rectum. Subject must have metastatic disease or locally recurrent disease that is not amenable to surgical resection with curative intent.
Subject must have received one prior chemotherapy regimen containing irinotecan or a fluoropyrimidine for locally recurrent or metastatic colon or rectal cancer.
Subject has experienced progressive disease during or following the previous anti-tumor treatment.
Subject may have received prior adjuvant treatment for colorectal cancer. Subject has measurable disease by RECIST criteria (randomized portion only). Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-1. Subject must have adequate bone marrow, renal and hepatic function. Subject must have Partial Thromboplastin Time (PTT) < 1.5 x Upper Limit of Normal (ULN) and International Normalized Ratio (INR) < 1.5.
Subject has received more than one prior therapy in the metastatic setting. Lead-in Cohort only: The subject may have received more than one prior therapy in the metastatic setting.
Subject has received cytotoxic chemotherapy within 21 days prior to Study Day 1.
Subject has received non-cytotoxic, anti-cancer therapy within 21 days or within a period defined by 5 half lives whichever is shorter, prior to Study Day 1.
Subject has not recovered to less than or equal to Grade 1 clinically significant adverse effects/toxicities of the previous therapy.
Subject has received prior treatment with a tyrosine kinase inhibitor targeting VEGF or PDGF.
Subject has received prior treatment with oxaliplatin in the metastatic setting. Lead-in cohort only: Prior treatment with oxaliplatin will be allowed provided that any neuropathy as a result of the oxaliplatin treatment has resolved to less than or equal to Grade 1.
Subject has had major surgery within 28 days of Study Day 1. Subject has had radiotherapy within 14 days of Study Day 1. Subject has a history of hypersensitivity to recombinant murine monoclonal antibodies, oxaliplatin or other platinum-containing compounds, fluorouracil, or folinic acid.
Subject has a known intolerance to bevacizumab. Subject has untreated brain or meningeal metastases. Subject is receiving therapeutic anticoagulation therapy . Subject has a history of/or currently exhibits clinically significant cancer related events of bleeding.
Subject currently exhibits symptomatic or persistent, uncontrolled hypertension.
Subject has a history of myocardial infarction, stroke, or transient ischemic attack within six months of Study Day 1.
History of another active cancer within the past 5 years except cervical cancer in situ, in situ carcinoma of the bladder, squamous cell or basal cell carcinoma of the skin.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description B folinic acid Open-label to High-dose ABT-869 arm plus mFOLFOX6 A bevacizumab Open-label to Bevacizumab plus mFOLFOX6 A oxaliplatin Open-label to Bevacizumab plus mFOLFOX6 A folinic acid Open-label to Bevacizumab plus mFOLFOX6 A fluorouracil Open-label to Bevacizumab plus mFOLFOX6 B ABT-869 Open-label to High-dose ABT-869 arm plus mFOLFOX6 B oxaliplatin Open-label to High-dose ABT-869 arm plus mFOLFOX6 B fluorouracil Open-label to High-dose ABT-869 arm plus mFOLFOX6 C ABT-869 Open-label to low-dose ABT-869 arm plus mFOLFOX6 C folinic acid Open-label to low-dose ABT-869 arm plus mFOLFOX6 C oxaliplatin Open-label to low-dose ABT-869 arm plus mFOLFOX6 C fluorouracil Open-label to low-dose ABT-869 arm plus mFOLFOX6
- Primary Outcome Measures
Name Time Method Progression-free survival Radiographic evaluation every 2 months, clinial evaluation every 2 weeks
- Secondary Outcome Measures
Name Time Method Overall survival from randomization until patient death or alive at 5 years 12-month overall survival rate from randomization until patient death or alive at 5 years Objective response rate from randomization until patient death or alive at 5 years
Trial Locations
- Locations (46)
Site Reference ID/Investigator# 11341
🇺🇸Chapel Hill, North Carolina, United States
Site Reference ID/Investigator# 20801
🇺🇸Philadelphia, Pennsylvania, United States
Site Reference ID/Investigator# 18581
🇦🇺Bedford Park, Australia
Site Reference ID/Investigator# 23265
🇨🇦Barrie, Canada
Site Reference ID/Investigator# 18281
🇰🇷Seoul, Korea, Republic of
Site Reference ID/Investigator# 18026
🇧🇪Leuven, Belgium
Site Reference ID/Investigator# 20281
🇳🇿Wellington South, New Zealand
Site Reference ID/Investigator# 8360
🇺🇸Nashville, Tennessee, United States
Site Reference ID/Investigator# 18022
🇧🇪Roeselare, Belgium
Site Reference ID/Investigator# 38284
🇵🇱Warsaw, Poland
Site Reference ID/Investigator# 22807
🇪🇸Barcelona, Spain
Site Reference ID/Investigator# 22801
🇪🇸Madrid, Spain
Site Reference ID/Investigator# 26662
🇧🇷Jau, Brazil
Site Reference ID/Investigator# 22141
🇨🇿Nachod, Czech Republic
Site Reference ID/Investigator# 22286
🇬🇷Thessaloniki, Greece
Site Reference ID/Investigator# 22324
🇵🇹Coimbra, Portugal
Site Reference ID/Investigator# 23724
🇵🇹Faro, Portugal
Site Reference ID/Investigator# 22809
🇪🇸A Coruna, Spain
Site Reference ID/Investigator# 23443
🇦🇺Herston, Australia
Site Reference ID/Investigator# 20141
🇵🇱Olsztyn, Poland
Site Reference ID/Investigator# 22804
🇪🇸Madrid, Spain
Site Reference ID/Investigator# 22803
🇪🇸Pamplona Navarra, Spain
Site Reference ID/Investigator# 25063
🇷🇺Moscow, Russian Federation
Site Reference ID/Investigator# 17962
🇷🇴Bucharest, Romania
Site Reference ID/Investigator# 17964
🇷🇴Bucharest, Romania
Site Reference ID/Investigator# 17961
🇷🇴Cluj Napoca, Romania
Site Reference ID/Investigator# 24422
🇷🇺Moscow, Russian Federation
Site Reference ID/Investigator# 18282
🇰🇷Seoul, Korea, Republic of
Site Reference ID/Investigator# 22800
🇪🇸Santander, Spain
Site Reference ID/Investigator# 22465
🇨🇦Ottawa, Canada
Site Reference ID/Investigator# 25065
🇷🇺Moscow, Russian Federation
Site Reference ID/Investigator# 24245
🇧🇷Porto Alegre, Brazil
Site Reference ID/Investigator# 21083
🇨🇦Edmonton, Canada
Site Reference ID/Investigator# 18283
🇰🇷Seoul, Korea, Republic of
Site Reference ID/Investigator# 23302
🇷🇴Brasov, Romania
Site Reference ID/Investigator# 23304
🇷🇴Bucharest, Romania
Site Reference ID/Investigator# 18023
🇧🇪Bonheiden, Belgium
Site Reference ID/Investigator# 17946
🇵🇱Warsaw, Poland
Site Reference ID/Investigator# 23303
🇷🇴Baia Mare, Romania
Site Reference ID/Investigator# 22287
🇬🇷Thessaloniki, Greece
Site Reference ID/Investigator# 23908
🇵🇹Aveiro, Portugal
Site Reference ID/Investigator# 23964
🇵🇹Lisbon, Portugal
Site Reference ID/Investigator# 23646
🇧🇪Brussels, Belgium
Site Reference ID/Investigator# 22289
🇬🇷Heraklion, Greece
Site Reference ID/Investigator# 24423
🇷🇺Moscow, Russian Federation
Site Reference ID/Investigator# 23305
🇷🇴Craiova, Romania