Comparison of haemodynamic changes with Rocuronium vs. Vecuronium for intubation of patients undergoing Laparoscopic appendicectomy under general anaesthesia: a double blind randomized controlled trial.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 96
- 试验地点
- 1
- 主要终点
- To compare changes in the mean artrial blood pressure and heart rate using Rocuronium and Vecuronium in patients undergoing laparoscopic appendicectomy under general anaesthesia
研究概览
简要总结
Laparoscopic surgeries are minimally invasive, less painful and thus shorten the hospital stay. Transient self-limiting increase in heart rate and blood pressure is common sequelae of direct laryngoscopy and intubation and are potentially hazardous. Laryngoscopy, intubation, pneumoperitoneum and carbo-peritoneum - these are also accompanied by positional changes in Laparoscopic appendicectomy. This has increased the challenges of maintaining haemodynamic stability for the anaesthesiologists. So, in our study we are looking forward to identify whether Rocuronium is a better muscle relaxant as compared to conventional Vecuronium for the patients undergoing Laparoscopic Appendicectomy under General Anaesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 50.00 Year(s)（—）
- 性别
- All
入选标准
- •1.American Society of Anaesthesiologists (ASA) grade I and II 2.Patients undergoing Laparoscopic appendicectomy under General anaesthesia.
排除标准
- •1.Pregnant 2.Lactating mothers 3.Patient with hypersensitivity to any of the research drugs 4.Patients undergone clinical trial within 3 months 5.Anticipated difficult airway
- •Patients having contraindication for laparoscopic surgeries 7.Severe Systemic diseases(Hypertension, Diabetes Mellitus, Seizure Disorder, Neurological Disorders, etc.).
结局指标
主要结局
To compare changes in the mean artrial blood pressure and heart rate using Rocuronium and Vecuronium in patients undergoing laparoscopic appendicectomy under general anaesthesia
时间窗: 1.Before intubation | 2.Just after intubation | 3.15 minutes after intubation | 4.30 minutes after intubation
次要结局
- To compare the ease of intubation between the two groups(During intubation)
- To compare the adverse events of the two muscle relaxants used(12 hours post-operative period)
研究者
Priya Gupta
College of Medicine and Sagore Dutta Hospital