Metabolic Modulation as Treatment in Acute Heart Failure
- Conditions
- Acute Heart Failure
- Registration Number
- NCT00449423
- Lead Sponsor
- University of Aarhus
- Brief Summary
The primary objective of this study is to evaluate whether metabolic modulation improves hemodynamics and outcome in acute heart failure
- Detailed Description
Acute heart failure is a serious disease that despite modern therapies carries a high mortality. Inotropic drugs improve patient status but yield a higher risk of death. Previous studies have shown that myocardial contractility improves when glucose fermentation is up regulated and decreases when Free Fatty Acids are high. In a placebo-controlled design we wish to shift myocardial substrate metabolism towards increased glucose uptake and utilization and measure hemodynamics and biochemical markers of metabolism and prognosis.
Recruitment & Eligibility
- Status
- TERMINATED
- Sex
- All
- Target Recruitment
- 32
- Acute heart failure
- NYHA class III - IV.
- ejection fraction <35
- Age <18 år or >85 år,
- allergy
- renal failure
- recently developed brady- or tachy-arrythmias
- Serious infection
- Heart failure due to restrictive or hypertrophic cardiomyopathy or stenotic valvular heart disease
- Recent Myocardial infarction (<6 Weeks)
- Pulmonary Wedge pressure >30 mm Hg
- diabetes mellitus treated with insulin
- peptic ulcer
- pregnancy
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Cardiac index pulmonary Wedge Pressure Ejection fraction
- Secondary Outcome Measures
Name Time Method outcome day 6 and 30 myocardial glucose- and Free Fatty Acid-extraction cardiac output Regional left ventricle function
Trial Locations
- Locations (1)
Aarhus University Hospital, Skejby Sygehus, Department of Cardiology
🇩🇰Aarhus, Denmark