Transcutaneous Vagus Nerve Stimulation Promotes Oxytocin Release and Increases Fixations on Nose
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 54
- 试验地点
- 1
- 主要终点
- Oxytocin release
研究概览
简要总结
The main aim of the study is to investigate whether the transcutaneous vagus nerve stimulation(tVNS) promotes oxytocin release and the potential biomarkers of tVNS based on eye-tracking data
详细描述
A randomized, single-blinded, sham-controlled, within-subject, crossover design will be employed in this study. In a randomized order, a total of 54 healthy subjects will receive transcutaneous vagus nerve stimulation via tragus and sham stimulation vis earlobe in the left ear (interval between these two stimulations will be 1 week). Eye-tracking and behavioral data will be collected before and after 30 minutes of stimulation, saliva samples will be collected before and after 30 minutes of stimulation, and the end of the experiment.
Some personal traits will be assessed using different kinds of questionnaires, such as the Autism Spectrum Quotient(ASQ), Social Responsiveness Scale(SRS), State-Trait Anxiety Inventory (STAI), Beck's Depression Inventory(BDI), and Toronto Alexithymia Scale (TAS-20).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 28 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects without past or current psychiatric or neurological disorders
排除标准
- •history of head injury;
- •pregnant, menstruating, taking oral contraceptives;
- •medical or psychiatric illness.
结局指标
主要结局
Oxytocin release
时间窗: After 30 min tragus stimulation
Investigating the oxytocin release after vagus nerve stimulation via tragus based on saliva samples
次要结局
- The relationship between oxytocin concentration and personal traits(through study completion, an average of half an year)
- Pupil size(After 30 min tragus stimulation)
研究者
Keith Kendrick
Professor
University of Electronic Science and Technology of China