Living Donor Liver Transplantation in Children

Completed

• Conditions: Pediatric Liver Transplanted Recipients; Healthy Donors

• Registration Number: NCT02124382
• Lead Sponsor: Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Brief Summary

Evaluate the outcome of pediatric living donor liver transplantation (LDLT) regarding portal vein reconstruction, ABO-compatibility and impact of maternal donation on graft acceptance.

Detailed Description

Data from 250 pediatric LDLT recipients (and their donors), transplanted at Cliniques universitaires Saint-Luc between July 1993 and June 2012, were collected retrospectively using electronic data files. Results were analysed according to ABO matching and portal vein complications. Uni- and multi-variate analysis was used to study the impact of immunosuppression, gender match and maternal donation on acute rejection rate.

Study Timeline

• Study Start: 2012-03
• Primary Completion: 2014-01
• Study Completion: 2014-03
• Status Verified: 2014-04
• Study First Submitted: 2014-04-24
• Study First Submitted QC: 2014-04-25
• Last Update Submitted: 2014-04-25
• Study First Posted: 2014-04-28
• Last Update Posted: 2014-04-28

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Children receiving a living donor liver transplant
• Adult living donors

Exclusion Criteria

• No one

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Patient and graft survival	10 years	Kaplan-Meier

Secondary Outcome Measures

Name	Time	Method
Portal vein complications	10 years