Effects of bilateral subthalamic nucleus deep brain stimulation on plasma triglycerides and glucose metabolism in patients with advanced Parkinson*s disease.
- Conditions
- Lipids and glucose metabolism in patients with Parkinson disease100211121001842410028037
- Registration Number
- NL-OMON31844
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 10
Patients with idiopathic Parkinson's disease, bilateral subthalamic nucleus deep brain stimulation, and a documented effect of bilateral subthalamic nucleus deep brain stimulation on parkinsonism *measured with the Unified Parkinson*s disease Rating Scale (UPDRS) motor section*equal or more than 75% of the difference between the preoperative provoked OFF and ON phases.
Age less than 18 years, other functional stereotactic neurosurgical interventions (e.g. pallidotomy), psychosis, depression, alcoholism, dyslipidemia (primary or secondary form), use of lipid lowering drugs, unstable weight, presence of type II diabetes mellitus, former history of diabetes gravidarum, first line familial preponderance of type II diabetes mellitus, active smoking, renal insufficiency (creatinine > 150 umol/L, creatinine clearance <60 ml/min) or elevated liver enzymes (2x upper limit).
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method