NL-OMON31844Not yet recruitingNot Applicable
Effects of bilateral subthalamic nucleus deep brain stimulation on plasma triglycerides and glucose metabolism in patients with advanced Parkinson*s disease. - Effects of subthalamic nucleus stimulation on metabolism
Trial Snapshot
- Phase
- Not Applicable
- Status
- Not yet recruiting
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 10
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •Patients with idiopathic Parkinson's disease, bilateral subthalamic nucleus deep brain stimulation, and a documented effect of bilateral subthalamic nucleus deep brain stimulation on parkinsonism *measured with the Unified Parkinson*s disease Rating Scale (UPDRS) motor section*equal or more than 75% of the difference between the preoperative provoked OFF and ON phases.
Exclusion Criteria
- •Age less than 18 years, other functional stereotactic neurosurgical interventions (e.g. pallidotomy), psychosis, depression, alcoholism, dyslipidemia (primary or secondary form), use of lipid lowering drugs, unstable weight, presence of type II diabetes mellitus, former history of diabetes gravidarum, first line familial preponderance of type II diabetes mellitus, active smoking, renal insufficiency (creatinine > 150 umol/L, creatinine clearance <60 ml/min) or elevated liver enzymes (2x upper limit).
Investigators
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