Effects of bilateral subthalamic nucleus deep brain stimulation on plasma triglycerides and glucose metabolism in patients with advanced Parkinson*s disease. - Effects of subthalamic nucleus stimulation on metabolism

Academisch Medisch Centrum0 个研究点目标入组 10 人开始时间: 待定最近更新: 2024年5月13日

试验速览

暂无简介。

•Patients with idiopathic Parkinson's disease, bilateral subthalamic nucleus deep brain stimulation, and a documented effect of bilateral subthalamic nucleus deep brain stimulation on parkinsonism *measured with the Unified Parkinson*s disease Rating Scale (UPDRS) motor section*equal or more than 75% of the difference between the preoperative provoked OFF and ON phases.

•Age less than 18 years, other functional stereotactic neurosurgical interventions (e.g. pallidotomy), psychosis, depression, alcoholism, dyslipidemia (primary or secondary form), use of lipid lowering drugs, unstable weight, presence of type II diabetes mellitus, former history of diabetes gravidarum, first line familial preponderance of type II diabetes mellitus, active smoking, renal insufficiency (creatinine > 150 umol/L, creatinine clearance <60 ml/min) or elevated liver enzymes (2x upper limit).

发起方