Recruitment Maneuver After Bronchoalveolar Lavage in ARDS Patients

Not Applicable

Not yet recruiting

• Conditions: Acute Respiratory Distress Syndrome
• Interventions: Other: Recruitment Maneuver

• Registration Number: NCT05372731
• Lead Sponsor: Southeast University, China

Brief Summary

ARDS caused by pneumonia is one of the main reasons for ICU admission in critically ill patients, and also a common complication in patients admitted to ICU with invasive mechanical ventilation. Bronchoalveolar lavage (BAL) is the main diagnostic method for these patients, which often leads to alveolar collapse and exacerbates hypoxemia. In clinical practice, recruitment maneuver (RM) is often used immediately after BAL to prevent such a situation, but there is a lack of data on RM after BAL.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2022-04-20
• Study First Submitted QC: 2022-05-12
• Study First Posted: 2022-05-13
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-27
• Last Update Posted: 2022-10-28
• Study Start: 2022-11-30
• Primary Completion: 2022-12-30
• Study Completion: 2022-12-30

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. Adult patients with invasive mechanical ventilation;
2. Patients who diagnosed with ARDS according to the Berlin definition
3. There are indications for bronchoalveolar lavage

Exclusion Criteria

1. Patients with contraindications for EIT procedures;
2. Patients with contraindications for RM;
3. Previous chronic respiratory diseases (long-term home oxygen therapy for chronic respiratory diseases such as pulmonary fibrosis or COPD);
4. Pregnancy;
5. Refusal to sign informed consent

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
RM after BAL	Recruitment Maneuver	patients underwent RM after BAL

Primary Outcome Measures

Name	Time	Method
the ratio of tidal volume in the BAL side and the other side	up to 24 hours	distribution of tidal volume monitored by electrical impedance tomography from the BAL side to the other side

Secondary Outcome Measures

Name	Time	Method
respiratory system compliance (the tidal volume to the driving pressure ratio)	up to 24 hours	respiratory system compliance was calculated by dividing expiratory tidal volume by the driving pressure (plateau pressure minus positive end-expiratory pressure)
partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio	up to 24 hours	partial pressure of arterial oxygen (Pao2) to the fraction of inspired oxygen (Fio2) ratio