Chen-style Tai Chi in Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease
- Conditions
- Chronic Obstructive Pulmonary Disease (COPD)
- Interventions
- Behavioral: Tai chiBehavioral: Conventional exercise
- Registration Number
- NCT02370654
- Lead Sponsor
- Laval University
- Brief Summary
This study will evaluate the effects of Chen-style Tai Chi compared to conventional exercise in pulmonary rehabilitation for COPD patients. Half of participants will receive the Chen-style Tai Chi intervention, while the other half will receive the conventional exercise intervention. Both groups will receive the same eduction and support during pulmonary rehabilitation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 44
- FEV1 between 30 and 80% of the predicted normal values
- FEV1/FVC ratio < 70%
- Patients with very severe COPD (GOLD IV);
- Patients that had a COPD exacerbations within the preceding 2 weeks of the baseline assessments;
- Significant hypoxemia at rest or during exercise (SpO2 <85%);
- Already following a rehabilitation program;
- Have physical limitations that compromises participation to a Tai chi and a conventional exercise program
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Tai Chi Tai chi 12 week Tai chi intervention, 3 sessions per week, 90 minutes per session Conventional exercise Conventional exercise 12 week conventional exercise intervention, 3 sessions per week, 90 minutes per session
- Primary Outcome Measures
Name Time Method Change from baseline dyspnea at 12 weeks Baseline, 12 weeks Dyspnea will be assessed using the chronic respiratory questionnaire (CRQ)
- Secondary Outcome Measures
Name Time Method Change from baseline lung function at week 12 (Spirometry and whole-body plethysmography) Baseline, 12 weeks Spirometry and whole-body plethysmography will be used for baseline and post-training (12 weeks) lung function testing.
Change from baseline of composite serum and plasma biomarkers at 12 weeks Baseline, 12 weeks During the baseline assessment and after the rehabilitation program, blood samples from patients will be taken in order to investigate the effect of the interventions on different biomarkers related to systemic inflammation.
Change from baseline isokinetic quadriceps muscle function at 12 weeks Baseline, 12 weeks Voluntary isokinetic quadriceps muscle function will be determined by quantification of force, endurance, and fatigability of the dominant quadriceps during a series of 30 repetitions at an angular velocity of 90°/s of a knee extension test.
Change from baseline physical activity at 12 weeks (participants will be equipped with a physical activity monitor) Baseline, 12 weeks To monitor physical activity, participants will be equipped with a physical activity monitor. The device will monitor the daily energy expenditure, the duration of physical activities above the pre-determined intensity level (Metabolic Equivalent of Task (MET) \>3), and also the total daily number of steps.
Change from baseline health status at 12 weeks (determined with the COPD Assessment test (CAT). Baseline, 12 weeks Impact of COPD on a person's life will be determined with the COPD Assessment test (CAT).
Change from baseline exercise capacity at 12 weeks(Endurance time during a constant work rate bicycle ergometry exercise test) Baseline, 12 weeks Endurance time during a constant work rate bicycle ergometry exercise test will be used to evaluate the exercise capacity of all participants at baseline and post-rehabilitation.
Change from baseline balance (Berg Balance Test (BBT) at 12 weeks Baseline, 12 weeks The Berg Balance Test (BBT) will be used to evaluate the effect of the interventions on patient's balance.
Change from baseline walking distance at 12 weeks (distance walked during the six-minute walk test) Baseline, 12 weeks The distance walked during the six-minute walk test will be used to evaluate the functional exercise capacity of all participants at baseline and post-rehabilitation.
Change from baseline isometric quadriceps muscle strength at 12 weeks (force of the dominant quadriceps will be measured during a single magnetic stimulation of the femoral nerve) Baseline, 12 weeks The force of the dominant quadriceps will be measured during a single magnetic stimulation of the femoral nerve (Twitch force of the quadriceps \[Twq\]) and during a maximum voluntary contraction (MVC).
Change from baseline quality of life (QoL) at 12 weeks Baseline, 12 weeks In addition to dyspnea (primary outcome), the CRQ will be used also to measure other physical-functional limitations due to COPD with questions related to fatigue and energy levels.
Trial Locations
- Locations (1)
Institut universitaire de cardiologie et de pneumologie de Québec
🇨🇦Quebec, Canada