Bolus eptifibatide versus bolus plus infusio

Phase 3

• Conditions: Condition 1: Acute ST elevation myocardial infarction. Condition 2: Acute ST elevation myocardial infarction. Condition 3: Acute ST elevation myocardial infarction. Condition 4: Acute ST elevation myocardial infarction.; ST elevation (STEMI) myocardial infarction of unspecified site; ST elevation (STEMI) myocardial infarction of anterior wall; ST elevation (STEMI) myocardial infarction of inferior wall; ST elevation (STEMI) myocardial infarction of other sites; I21.3; I21.0; I21.1; I21.2

• Registration Number: IRCT20110512006463N3
• Lead Sponsor: Deputy of research and technology of Alborz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 April 2021

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 163

Inclusion Criteria

Patients with symptoms of ischemic heart attack that last no longer than 12 hours with 1 mm ST elevation in at least 2 limb leads or 2 mm ST elevation in at least 2 precordial leads who are candidates for Primary PCI intervention.

Exclusion Criteria

Not acceptance of informed consent
History of sensitivity to eptifibatide, heparin or aspirin
Recent treatment with warfarin (INR>2), fibrinolythics or other IIbIIIa inhibitors
Platelet <100000/mcL
Known bleeding disorder
History of ischemic cerebrovascular accident in previous 30 days
History of hemorrhagic cerebrovascular accident
Abnormal bleeding in recent 30 days.
Major surgery in previous 6 weeks
Renal failure with dependency to hemodialysis
Uncontrolled hypertension (SBP>200mmHg, or DBP>110mmHg)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Vascular or bleeding complication. Timepoint: During in-hospital admision. Method of measurement: Questionnaire and physical exam.

Secondary Outcome Measures

Name	Time	Method
Death. Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Myocardial infarction. Timepoint: 2 days and 6 months after intervention. Method of measurement: ECG and increase in CKMB.;Need for target lesion revascularization (TLR). Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Need for target vessel revascularization (TVR). Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Need for coronary artery bypass graft (CABG). Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.;Cerebrovascular accidents. Timepoint: 2 days and 6 months after intervention. Method of measurement: Questionnaire, Electronic file.