Role of supplementation of Vitamin D in prevention of preeclampsia

The study will be conducted in the Department of Obstetrics and Gynecology and Department of Biochemistry at Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, New Delhi. It will be a Prospective case control type of study. Duration of the study will be from 11th June 2025 to 10th November 2026.Sample size -In a study A prospective comparative interventional study by by Sinha et al. (2019)22 in Bhagalpur, Bihar, involved 60 pregnant women divided into two groups. The incidence of preeclampsia was 16.7 percent in the non-supplemented group compared to 6.7 percent in the vitamin D supplemented group, indicating a significant reduction in risk (p equal to 0.041) . Based on the formula and values given above, the sample size calculated per group is approximately 267 (total 534). Thus, with 80 percent power and 95 percent confidence interval, the minimum sample size required for the study is 267 in each group (total 534). It is proposed to recruit 125 pregnant women in each group (case and control groups) as a convenient sample size, which makes a total of 250.