Can a feeding protocol improve clinical outcomes in critically ill patients?

Not Applicable

Completed

• Conditions: Critically ill patients; Injury, Occupational Diseases, Poisoning

• Registration Number: ISRCTN12233792
• Lead Sponsor: anjing Central Hospital

Brief Summary

2022 Results article in https://pubmed.ncbi.nlm.nih.gov/36118758/ (added 20/09/2022) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/36314372 Secondary analysis (added 20/12/2023) 2022 Other publications in https://pubmed.ncbi.nlm.nih.gov/35767914/ Secondary analysis (added 20/12/2023) 2022 Results article in https://pubmed.ncbi.nlm.nih.gov/35172856 (added 20/12/2023) 2024 Results article in https://doi.org/10.1186/s13054-024-04813-6 post hoc analysis (added 22/01/2024)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-11-24
• Study Completion: 2019-12-28
• Last Update Posted: 5 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 2772

Inclusion Criteria

Current inclusion criteria as of 15/01/2020:
1. Informed consent form obtained from the patient or next of kin
2. Aged 18 years or older
3. Within 24 h of ICU admission
4. With one or more organ failure (SOFA for any single organ system=2)
5. Expected to stay in ICU more than 7 days
6. Oral diet is not likely to be restored within three days

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Previous inclusion criteria:
1. All patients expected to stay in ICU for over three days
2. Aged 18 years and older

Exclusion Criteria

Current exclusion criteria as of 15/01/2020:
1. Received EN in the past 3 days
2. Receiving palliative treatment or expected to die within 48 hours
3. Women in pregnancy
4. Long-term use of steroids or immunosuppressive agents
5. Patients with malignant diseases receiving radiotherapy or chemotherapy.

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Previous exclusion criteria:
1. Subjects receiving EN in previous 7 days
2. Contraindications for nasogastric or nasoenteric tube placement
3. Subjects who have already undergone percutaneous endoscopic jejunostomy (PEJ), percutaneous endoscopic gastrostomy (PEG) and surgical jejunostomy
4. Age younger than 18 years old
5. Women who are pregnant or undergo breast feeding
6. Burn patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified