NL-OMON38325
Completed
Not Applicable
Randomised controlled study of dose reduction and withdrawal strategies of adalimumab and etanercept in rheumatoid arthritis: saving costs at what expense? - DRESS study: Dose REduction Strategies of Subcutaneous TNF inhibitors
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- chronic arthritis
- Sponsor
- Sint Maartenskliniek
- Enrollment
- 180
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •\- Rheumatoid arthritis (either 2010 ACR RA and/or 1987 RA criteria and/or clinical diagnosis of the treating rheumatologist, fulfilled at any time point between start of the disease and inclusion)
- •\- Using either adalimumab or etanercept (all dose/interval regimens, all background medication including DMARDs and corticosteroids up to 5 mg, higher doses of steroids should be reduced first)
- •\- 6 months of stable low disease activity while using adalimumab or etanercept (operationalised by either a DAS28 \< 3\.2 or judgment of low disease activity by rheumatologist at at least two subsequent visits)
- •\- 6 months stable treatment with adalimumab or etanercept (previous dose reduction/interval increase is allowed when more than three months ago) and stable DMARDs and corticosteroids for more than 4 weeks
Exclusion Criteria
- •\- Co morbidity that also requires treatment with anti\-TNF and thus prevents dose reduction
Outcomes
Primary Outcomes
Not specified
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