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临床试验/ACTRN12619000907145
ACTRN12619000907145已完成未知

Prophylactic enoxaparin use and outcomes in obese patients undergoing laparoscopic adjustable gastric band surgery

Dr Syed Tabish Razi Zaidi0 个研究点目标入组 212 人开始时间: 2019年6月27日最近更新:

试验速览

阶段
未知
状态
已完成
发起方
入组人数
212

研究概览

简要总结

There is a lack of clear guidance for the prophylactic use of anticoagulants for patients undergoing laparoscopic adjustable gastric banding (LAGB) surgery. This study aimed to evaluate the risk of venous thromboembolism (VTE), prophylactic use of enoxaparin and clinical outcomes in patients undergoing primary and revisional LAGB procedures. A retrospective cohort study evaluated the prophylactic use of enoxaparin in adult patients who underwent primary and revisional (band and port) LAGB procedures. The incidence of VTE and major bleeding was investigated during a 90-day follow-up period. We included 112 and 100 patients who had undergone primary and revisional LAGB surgery, respectively. The majority of patients (97%) had a mild risk of VTE development using a post-discharge VTE risk calculator tool published from the Cleveland Clinic. Overall, 69% patients received standard enoxaparin dose i.e 40 mg once daily. All primary procedure patients received prophylactic enoxaparin, compared to 79% and 20% of revisional patients who underwent band and port procedures, respectively. Use of enoxaparin was more common in patients admitted overnight. The overall VTE incidence after 90 days was 0.9%, and no major bleeding events were observed. Obese patients received standard 40 mg daily dose of enoxaparin. No higher doses was given to obese patients, likely because LAGB is low risk surgical procedure.

研究设计

研究类型
Observational

入排标准

年龄范围
18 Years 至 o limit(—)
性别
All

入选标准

  • A retrospective cohort study was conducted of adult (age greater than or equal to 18 years) obese patients (BMI more than or equal to 30 kg/m2) who underwent primary and revisional bariatric surgery at the Royal Hobart Hospital (RHH) and the Hobart Private Hospital (HPH), from 1 Jan 2013 to 31 Dec 2017

排除标准

  • Patients were excluded from the study if they were on regular anticoagulant or vitamin K therapy, underwent a concurrent surgical procedure (e.g. hysterectomy), or had an established congenital or acquired bleeding disorder, varicose veins, renal impairment with an estimated glomerular filtration rate < 60 mL/min/1.73m2, prior heparin-induced thrombocytopaenia, haemorrhagic stroke within the previous 3 months, other surgery within the previous 3 months, or if relevant information was missing.

研究者

发起方
Dr Syed Tabish Razi Zaidi

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