Effect of Non-Surgical Periodontal Therapy on Salivary and Gingival Crevicular Fluid YKL-40 and IL-6 Levels in Chronic Periodontitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 52
- 主要终点
- YKL-40 levels
研究概览
简要总结
The primer aim of the study was to investigate saliva and gingival crevicular fluid (GCF) YKL-40 and also interleukin-6 (IL-6) levels in chronic periodontitis pathogenesis.
详细描述
This study consisted of two groups: 26 periodontally healthy individuals and 26 generalized chronic periodontitis patients. Chronic periodontitis patients were received nonsurgical periodontal treatment. Clinical measurements were recorded, saliva and GCF samples were obtained before and at first and third months after periodontal therapy. Levels of YKL-40 and IL-6 in saliva and GCF were analyzed by enzyme-linked immunosorbent assay.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 26 Years 至 49 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Group 1 Inclusion Criteria:
- •No bone and attachment loss,
- •GI=0, PPD≤3mm, CAL≤3mm
- •Systematically healthy patients
- •Group 2 Inclusion Criteria:
- •GI>1, PPD≥5mm, CAL≥5mm with alveolar bone loss radiographically.
- •Systematically healthy patients
排除标准
- •Aggressive Periodontitis,
- •Patients with any other systemic diseases,
- •Pregnant women and those in the lactation period,
- •Patients with smoking habit and taking medication
- •Patients received periodontal therapy in last 6 month
结局指标
主要结局
YKL-40 levels
时间窗: at first and third month after therapy
changes in YKL-40 levels after periodontal therapy
次要结局
- IL-6 levels(at first and third month after therapy)
研究者
Zeynep Pinar KELES
ZEYNEP PINAR KELEŞ
Aydin Adnan Menderes University