Managerial Database II

Completed

Brief Summary: This study will collect information on health status and risk behaviors, as well as basic demographic and biomedical information for a group of HIV positive adolescents receiving care at the ATN sites.

Detailed Description: The proposed study is a cross sectional study intended to be conducted at each of the 15 Adolescent Medicine Trials Units (AMTUs) participating in the ATN and to enroll all participating patients followed at each site. This approach will allow for the examination of the broad spectrum of youth participating in the ATN, including those newly entered into care.

Psychosocial and risk-taking behavioral data will be collected using Audio Compute-Assisted Self-Interview (ACASI); biomedical information will be collected through medical chart abstraction.

Recruitment & Eligibility

Inclusion Criteria

Laboratory evidence of HIV-1 infection documented by a positive result on any of the following licensed tests at any time: Any HIV-1 antibody test confirmed by Western blot, HIV-1 culture, HIV-1 DNA PCR, or plasma HIV-1 RNA PCR > 1,000 copies/ml;
Knowledge of HIV positive diagnoses;
Age 12 years through 24 years, inclusive;
Engaged in care at the AMTU or its affiliate and/or partnering clinic. Individuals will be considered to be engaged in care if:
Diagnosed less than or equal to 12 months prior to the date of approval to generate the master list and has attended a minimum of one visit since diagnosis for the management of HIV disease or its sequelae; or
Diagnosed more than 12 months prior to the date of approval to generate the master list and has had a minimum of one visit, as described above, within the past 12 months.
Ability to understand written and/or verbal English
Ability and willingness to provide signed consent/assent;
Parental/legal guardian permission (if applicable)

Exclusion Criteria

Presence of serious psychiatric symptoms (e.g., active hallucinations, thought disorder) that would impair the individuals' ability to complete the study measures;
Visibly distraught (e.g., suicidal, homicidal, exhibiting violent behavior); or
Intoxicated or under the influence of alcohol or other substances at the time of consent/assent.

Arm && Interventions

Group	Intervention	Description
AMTU Clients	Observation	All HIV-infected adolescents and young adults engaged in care at the 15 sites and their affiliates who are between 12 and 24 years of age, inclusive, are aware of their HIV status and understand written and/or verbal English will be eligible for inclusion in the study. In addition, new patients who have their initial clinic visit within the enrollment period will also be eligible for participation.

Primary Outcome Measures

Name	Time	Method
Rates of adherence to medical regimens, sexual risk behavior, substance use and mental health concerns; basic demographic and biomedical data for adolescents and young adults with HIV infection engaged in care at the AMTUs.	within 2 weeks of enrollment

Secondary Outcome Measures

Name	Time	Method
To better understand the complex relationships between adherence to medical regimens, sexual risk behavior, substance use and mental health concerns, and basic demographic and biomedical data in adolescents and young adults with HIV infection.	1.3 years

Locations (15): Childrens Hospital of Philadelphia
🇺🇸
Philadelphia, Pennsylvania, United States
Ruth M Rothstein CORE Center/ John H Stroger Jr Hospital
🇺🇸
Chicago, Illinois, United States
Childrens National Medical Center
🇺🇸
Washington, District of Columbia, United States
Childrens Diagnostic & Treatment Center
🇺🇸
Fort Lauderdale, Florida, United States
Childrens Hospital Los Angeles
🇺🇸
Los Angeles, California, United States
Childrens Memorial Hospital
🇺🇸
Chicago, Illinois, United States
Mount Sinai Medical Center
🇺🇸
NY, New York, United States
University of Maryland
🇺🇸
Baltimore, Maryland, United States
St. Jude Childrens Research Hospital
🇺🇸
Memphis, Tennessee, United States
University of Puerto Rico
🇵🇷
San Juan, Puerto Rico
University of California San Francisco
🇺🇸
San Francisco, California, United States
University of Miami School of Medicine
🇺🇸
Miami, Florida, United States
University of South Florida
🇺🇸
Tampa, Florida, United States
Tulane University Health Sciences Center
🇺🇸
New Orleans, Louisiana, United States
Montefiore Medical Center
🇺🇸
Bronx, New York, United States