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临床试验/NCT04196504
NCT04196504Unknown不适用

Prevalence of Echocardioghraphic and ECG Changes in Patients With Acute Pancreatitis and Its Impact on Outcome.

Assiut University0 个研究点目标入组 30 人开始时间: 2019年12月31日最近更新:
适应症

试验速览

阶段
不适用
入组人数
30
主要终点
determine the impact of these changes on outcome of patients

研究概览

简要总结

Cardiovascular system involvement with acute pancreatitis has been described before in the form of ECG changes and echocardiographic findings. However the correlation between these changes and the outcome of acute pancreatitis has not been and whether they can be used to predict mortality in these patients has been controversial.In the current study our aim is to detect echocardioghraphic and ECG changes in acute pancreatitis and investigate the significance of these changes on prognosis.

详细描述

Acute pancreatitis is a relatively common disease with significant morbidity and mortality. About 75% of pancreatitis is caused by gallstones or alcohol. The Atlanta classification of acute pancreatitis has been used to differentiate between severe and mild cases of acute pancreatitis. According to this classification, patients are diagnosed with severe acute pancreatitis if they show evidence of organ failure, Local complications (eg, necrosis, abscess, pseudocyst), Ranson score of 3 or higher or APACHE score of 8 or higher. Severe acute pancreatitis has a wide range of affection on nearly all body systems with various degrees of affection than affect both the clinical picture and the prognosis of the disease. the cardiovascular system involvement has been described before ,in the form of ECG changes (sinus tachycardia, arrhythmias, conduction abnormalities.. ) and echocardiographic findings (diastolic,systolic or combined dysfunction, wall motion abnormalities, pericardial effusion..). However the correlation between these changes and the outcome of acute pancreatitis has not been and whether they can be used to predict mortality in these patients has been controversial.In the current study our aim is to detect echocardioghraphic and ECG changes in acute pancreatitis and investigate the significance of these changes on prognosis.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 80 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •all patients with acute pancreatitis aged more than 18 yrs admitted to Al-raghy ICU of all etiologies

排除标准

  • •patients less that 18 years
  • •patients above 80 years
  • •patients with known cardiac disease
  • •patients with pre-existing diabetes, chronic renal failure or malignancy.
  • •patients with underlying chronic pancreatitis

结局指标

主要结局

determine the impact of these changes on outcome of patients

时间窗: though out hospital admission (an average of 1 week)

determine the impact of these changes on outcome of patients

Echocardiographic (mainly diastolic dysfunction & pericardial effusion) and ECG changes (mainly QT interval) in patients with acute pancreatitis.

时间窗: at admission on 1st day

To detect the echocardiographic (mainly diastolic dysfunction \& pericardial effusion) and ECG changes (mainly QT interval) in patients with acute pancreatitis.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Alaaeldin Mahmoud Ibrahim Abdelrahman

Principal Investigator

Assiut University

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