Prevalence of Echocardioghraphic and ECG Changes in Patients With Acute Pancreatitis and Its Impact on Outcome.
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 主要终点
- determine the impact of these changes on outcome of patients
研究概览
简要总结
Cardiovascular system involvement with acute pancreatitis has been described before in the form of ECG changes and echocardiographic findings. However the correlation between these changes and the outcome of acute pancreatitis has not been and whether they can be used to predict mortality in these patients has been controversial.In the current study our aim is to detect echocardioghraphic and ECG changes in acute pancreatitis and investigate the significance of these changes on prognosis.
详细描述
Acute pancreatitis is a relatively common disease with significant morbidity and mortality. About 75% of pancreatitis is caused by gallstones or alcohol. The Atlanta classification of acute pancreatitis has been used to differentiate between severe and mild cases of acute pancreatitis. According to this classification, patients are diagnosed with severe acute pancreatitis if they show evidence of organ failure, Local complications (eg, necrosis, abscess, pseudocyst), Ranson score of 3 or higher or APACHE score of 8 or higher. Severe acute pancreatitis has a wide range of affection on nearly all body systems with various degrees of affection than affect both the clinical picture and the prognosis of the disease. the cardiovascular system involvement has been described before ,in the form of ECG changes (sinus tachycardia, arrhythmias, conduction abnormalities.. ) and echocardiographic findings (diastolic,systolic or combined dysfunction, wall motion abnormalities, pericardial effusion..). However the correlation between these changes and the outcome of acute pancreatitis has not been and whether they can be used to predict mortality in these patients has been controversial.In the current study our aim is to detect echocardioghraphic and ECG changes in acute pancreatitis and investigate the significance of these changes on prognosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all patients with acute pancreatitis aged more than 18 yrs admitted to Al-raghy ICU of all etiologies
排除标准
- •patients less that 18 years
- •patients above 80 years
- •patients with known cardiac disease
- •patients with pre-existing diabetes, chronic renal failure or malignancy.
- •patients with underlying chronic pancreatitis
结局指标
主要结局
determine the impact of these changes on outcome of patients
时间窗: though out hospital admission (an average of 1 week)
determine the impact of these changes on outcome of patients
Echocardiographic (mainly diastolic dysfunction & pericardial effusion) and ECG changes (mainly QT interval) in patients with acute pancreatitis.
时间窗: at admission on 1st day
To detect the echocardiographic (mainly diastolic dysfunction \& pericardial effusion) and ECG changes (mainly QT interval) in patients with acute pancreatitis.
次要结局
未报告次要终点
研究者
Alaaeldin Mahmoud Ibrahim Abdelrahman
Principal Investigator
Assiut University
