A Dose-response Study of Dietary Resveratrol on Lipid Metabolism Disorder
- Conditions
- Dyslipidemias
- Interventions
- Registration Number
- NCT04886297
- Lead Sponsor
- Sun Yat-sen University
- Brief Summary
In order to study the effect of resveratrol on the improvement of lipid and uric acid metabolism, randomized intervention trials were conducted to compare the effects of resveratrol on the improvement of lipid and uric acid metabolism in different dose groups. To explore the best dose of resveratrol for the prevention and treatment of metabolic diseases provide an important scientific basis.
- Detailed Description
In order to study the effect of resveratrol on the improvement of lipid and uric acid metabolism, randomized controlled trials were conducted to enrolled 160 patients with dyslipidemia. The subjects were divided into 0 mg / d, 100 mg / d, 300 mg / d, 600 mg/ d four dose groups, intervention for 8 weeks, comparing different doses of resveratrol on lipid and uric acid metabolism. To explore the best dose of resveratrol for the prevention and treatment of metabolic diseases provide an important scientific basis.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 168
- Dyslipidemia
- The age between 35 and 70 years old
- Intake of any medicine that affect lipid metabolism currently or in the preceding 6 months
- Dietary supplementation with phytochemicals including resveratrol in the preceding 3 months
- History of acute or chronic infectious disease, autoimmune disease, cancer, traumatic injury, or surgery in the preceding 1 month
- History of severe chronic disease including AS and CVD, liver or renal dysfunction, and lactation or pregnancy
- Pregnant woman and Breast Feeding Women
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description 300mg/d resveratrol Mega Resveratrol® capsules During the trial period, the participants will be instructed to consume one Mega Resveratrol® capsules and one Mega Resveratrol® placebo capsules 30 min after breakfast. The resveratrol capsules (300 mg anthocyanins per capsule) will provid a total daily intake of 300 mg resveratrol. Intervention: Drug: Mega Resveratrol® capsules 600mg/d resveratrol Mega Resveratrol® capsules During the trial period, the participants will be instructed to consume two Mega Resveratrol® capsules 30 min after breakfast. The resveratrol capsules (300 mg anthocyanins per capsule, 2 per day) will provid a total daily intake of 600 mg resveratrol. Intervention: Drug: Mega Resveratrol® capsules placebo Mega Resveratrol® Placebo capsules The placebo capsules only contained pullulan and maltodextrin. During the trial period, the participants were instructed to consume two Mega Resveratrol® placebo capsules once daily (30 min after breakfast). Intervention: Drug: Mega Resveratrol® capsules 100mg/d resveratrol Mega Resveratrol® capsules During the trial period, the participants will be instructed to consume one Mega Resveratrol® capsules and one Mega Resveratrol® placebo capsules 30 min after breakfast. The resveratrol capsules (100 mg anthocyanins per capsule) will provid a total daily intake of 100 mg resveratrol. Intervention: Drug: Mega Resveratrol® capsules
- Primary Outcome Measures
Name Time Method Effect of resveratrol on lipid profile in patients with dyslipidemia Change from Baseline to 4 weeks and 8 weeks Lipid profile in serum will be measured, mainly including TC, TG, LDL-C and HDL-C, by automatic biochemical analyzer.
- Secondary Outcome Measures
Name Time Method Effect of resveratrol on uric acid and xanthine oxidase in patients with dyslipidemia Change from Baseline to 4 weeks and 8 weeks Uric acid concentration and xanthine oxidase activity will be measured by automatic biochemical analyzer and commercial kits, respectively.
Trial Locations
- Locations (1)
Sun Yat-Sen University
🇨🇳Guangzhou, Guangdong, China