Effect of nebulized Budesonide on respiratory mechanics and oxygenation in patients with acute lung injury/acute respiratory distress syndrome: A prospective clinical study.

Recruiting

• Conditions: Acute lung injury.; Acute respiratory distress syndrome.; Anaesthesiology - Other anaesthesiology; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12615000373572
• Lead Sponsor: South valley university

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-04-23
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

Patients should fulfill the criteria of ALI/ARDS according to 2012 Berlin definition of ALI/ARDS

Exclusion Criteria

Refusal of consent by relatives,age <18 or>65 years,chronic obstructive pulmonary disears,restrictive respiratory insufficiency,increased intracranial pressure, bronchpleural fistula,acute myocardial infarction and neuromuscular disease.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Pao2/fio2 ; it is calculated from the measured Pao2 ( from arterial blood gas analysis) and the inspired oxygen concentration. Fio2 is the inspired fraction of oxygen given by anesthesiologist whether pure oxygen(i.e 100% oxygen) or in combination with air(e.g. 60% oxygen in 40% air).<br><br><br><br><br>[basal( before nebulization) and after termination of 6 nebulization sessions ( i.e after 72 hours) with either budesonide or isotonic saline.]

Secondary Outcome Measures

Name	Time	Method
Peak inspiratory pressure(PIP)- plateau pressure.<br>Both parameters are assessed from the screen of Binnette re spirometer.<br>[basal( before nebulization) and after termination of 6 nebulization sessions( i.e after 72 hours) with either budesonide or isotonic saline.]