Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)

Completed

• Conditions: Lupus Erythematosus; Age Related Macular Degeneration; Lupus Erythematosus, Systemic
• Interventions: Procedure: Blood test

• Registration Number: NCT03504540
• Lead Sponsor: Fondation Ophtalmologique Adolphe de Rothschild

Brief Summary

The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients.

Based on the results obtained, this study could lead to future research that could better target the treatment of patients with lupus or patients with AMD (Age related Macular Degeneration).

The primary objective is to check if patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits have a different complement profile (functional exploration of complement, complement factors, genetic complement polymorphisms involved in AMD) compared to patients without "pseudo-drusen-like" deposits.

Detailed Description

Not available

Study Timeline

• Study Start: 2018-04-05
• Study First Submitted: 2018-04-06
• Study First Submitted QC: 2018-04-12
• Study First Posted: 2018-04-20
• Status Verified: 2021-05
• Primary Completion: 2021-05-15
• Study Completion: 2021-05-15
• Last Update Submitted: 2021-05-21
• Last Update Posted: 2021-05-24

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 42

Inclusion Criteria

• Systemic lupus erythematosus
• Case patients : with "pseudo-drusen-like" deposit
• Control patients : without "pseudo-drusen-like" deposit

Exclusion Criteria

• Patient under a measure of legal protection

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Control (without pseudo-drusen-like deposits)	Blood test	Patients with lupus, treated or not with antimalarial drugs, without "pseudo-drusen-like" deposits
Case (with pseudo-drusen-like deposits)	Blood test	Patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits

Primary Outcome Measures

Name	Time	Method
Comparison of complement factors between case and control patients	Baseline
Comparison of AMD genetic polymorphisms between case and control patients	Baseline

Trial Locations

Locations (1)

Fondation ophtalmologique Adolphe de Rothschild; 🇫🇷 Paris, France