To compare whether single collection or multiple collections requires drainage in patients with acute pancreatitis
- Conditions
- Health Condition 1: K85- Acute pancreatitis
- Registration Number
- CTRI/2022/07/043878
- Lead Sponsor
- o sponser
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
All patients of acute necrotizing pancreatitis with
1. Illness of more than 1 week duration
2. Two or more drainable collections at different locations as per definition given below
3. No response to antibiotic therapy for 72 hours.
4. Indication of drainage which will include
1. Persistent systemic inflammatory response syndrome (SIRS)
2. Clinically suspected or proven infected pancreatic necrosis
3. Persistent or new onset organ failure
All patients with acute necrotizing pancreatitis with
1. Patients aged < 12 years
2. Duration of illness less than 1 week
3. Patients with asymptomatic collections
4. Single collection
5. Patients requiring drainage of collection due to only pressure symptoms like abdominal
pain, biliary obstruction or gastric outlet obstruction
6. Previous intervention in any of the collections (drainage of ascites and pleural effusion
will not be an exclusion criteria)
7. Patients who do not give consent
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Comprehensive Complications Index (CCI), including all complications other than pre-existent complications (e.g. treatment for infected collection) occurring after randomization till the removal of all drains (percutaneous or endoscopic) or discharge whichever is later, and graded according to the Clavien-Dindo classificationTimepoint: At discharge or removal of catheter
- Secondary Outcome Measures
Name Time Method Bleeding requiring interventionTimepoint: At discharge or removal of all catheters;Enterocutaneous and pancreatic fistula <br/ ><br>Timepoint: At discharge or removal of all catheters;Length of hospital stay and length of ICU stay after randomization <br/ ><br>Timepoint: At discharge <br/ ><br>;MortalityTimepoint: Hospital mortality;New-onset (single or multiple) organ failureTimepoint: At discharge or removal of all catheters;Number of endoscopic and radiological interventions <br/ ><br>Timepoint: At discharge or removal of all catheters <br/ ><br>;Perforation of a visceral organ requiring interventionTimepoint: At discharge or removal of all catheters;Requirement of surgical intervention <br/ ><br>Timepoint: At discharge or removal of all catheters