Status and the Application of Topotecan at Post-operation Treatment of Cervical Cancer
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 183
- 试验地点
- 1
研究概览
简要总结
The purpose of the research is to evaluate the effect of additional chemotherapy in postoperation therapy of cervical cancer patients with risk factors (big tumor, deep invasion or tumor thrombi in the vascular system).
详细描述
Cervical cancer has a very high morbidity. Many patients need additional therapy after surgery in order to elevate the survival rate and life quality. In this research, we are going to give additional therapy to patients who have big tumor, deep invasion or tumor thrombi in the vascular system after surgery. randomized control method will be used in this research, in order to compare the survival rate and side effects between radiation therapy only, concurrent chemoradiotherapy, and concurrent chemoradiotherapy with additional chemotherapy. 3D-CRT and Topotecan will be used in this research.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 20 Years 至 70 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •patients who underwent the cervical cancer radical surgery in three months have higt risk factors which including deep stromal invasion,large primary tumour and/or lymphovascular spase invasion;
- •squamous carcinoma;
- •Gynecologic Oncology Group (GOG):0-2.
排除标准
- •negative nodes,surgical margin,and/or parametrium;
- •No serious damage to the liver and kidney function, no hypertension,diabetes and other effects of therapy complications.
研究者
Liu Zi
Profesor
Health Science Center of Xi'an Jiaotong University