Serial Changes in sTREM-1 During Ventilator-associated Pneumonia (VAP)
- Conditions
- Pneumonia
- Interventions
- Procedure: Bronchoscopy BAL
- Registration Number
- NCT00976157
- Lead Sponsor
- Mackay Memorial Hospital
- Brief Summary
Triggering receptor expressed on myeloid cells (TREM)-1 is a recently described molecule that plays an important role in myeloid cell-activated inflammatory responses. The aim of this study was to investigate the evolutional change of soluble TREM-1 (sTREM-1) in bronchoalveolar lavage (BAL) fluid of clinically diagnosed ventilator-associated pneumonia (VAP) and its correlation with response to treatment and outcome.
- Detailed Description
A prospective, interventional study conducted between August 2006 and August 2007 in MICU in Mackay Memorial Hospital, 35 patients with clinically diagnosed VAP were investigated. sTREM-1 was measured in BAL samples using ELISA at the onset, 4th - 5th and 7th - 9th day of clinical diagnosis of VAP.Of these 35 patients, 27 had positive BAL culture. The sTREM-1 levels in BAL fluid were measured and compared between patients with positive BAL culture and negative BAL culture. Serial changes in sTREM-1 levels were evaluated in relation to patient outcome.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 35
- adult patients (older than 18 years)with clinically suspected VAP
- mechanically ventilated patients post cardiopulmonary resuscitation
- patients with end stage diseases with life expectancy less than 3 months
- patients with solid or hematology transplantation
- patients on immunosuppressive agents
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Ventilator-associated pneumonia Bronchoscopy BAL -
- Primary Outcome Measures
Name Time Method mortality 18 months
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Mackay Memorial Hospital
🇨🇳Taipei, Taiwan