Perioperative Body Composition Changes in Patients Undergoing Gastrointestinal or Lung Cancer Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 374
- 试验地点
- 1
- 主要终点
- body composition
研究概览
简要总结
Denutrition and Obesity are risk factors for perioperative surgical complications.
In patient with cancer, incidence of denutrition is markedly increased. Surgical resection of cancer induces a high intensity cellular stress response and catabolism reinforcing the risk for perioperative denutrition.
In this study, we thought to investigate the change in body composition during the perioperative period using anthropometric measurements and Bioelectrical Impedance Analysis (BIA).
详细描述
Body composition measurements will be performed before surgical procedure (7 days) and at day 1, day 5, 1 month, 3 months and 6 months after surgery.
Others data will be recorded including anthropometric measurements, nutritional intake, occurence of surgical complication, type of surgical procedure, type and stage of cancer, and CT-scan measurements of subcutaneous abdominal fat, visceral fat and peri-renal fat before surgery and at 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Gastrointestinal cancer (esophagus, gastric, pancreatic, hepatic, colorectal and anal)
- •Or Lung cancer
- •And planned surgical resection
- •Age > 18 years
排除标准
- •Surgical procedure planned < 48 h
- •Pregnancy
- •Presence of a cardiac stimulator
结局指标
主要结局
body composition
时间窗: 1 month
The primary objective is to study the change in body composition (fat mass, lean body mass, muscular mass, mineral mass, total body water, intra and extracellular water) during the perioperative period with respect to short, mid and long term outcome.
次要结局
- perioperative complications(6 months)
研究者
Jerome Allardet-Servent, MD
MD, MSc
Hôpital Européen Marseille