Clinical Features, Microbiological-, Radiological Characteristics, and Differential Diagnosis of Vertebral Osteomyelitis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Identification of etiology of vertebral osteomyelitis
研究概览
简要总结
Vertebral osteomyelitis is a uncommon disease that can lead to neurologic deficits if not diagnosed in time. The etiologies of vertebral osteomyelitis include pyogenic bacteria, M. tuberculosis, Brucella species, and fungus. The aim of this study is to describe the clinical features and microbiological/radiological characteristics of patients with vertebral osteomyelitis, and investigate the useful tips for the differential diagnosis of vertebral osteomyelitis.
详细描述
Besides description of characteristics of patients with vertebral osteomyelitis, we also will investigate the usefulness of 16S rRNA gene sequence analysis of biopsy specimen. MRI findings during the antibiotic treatment will be monitored and compared for the differential diagnosis of meningitis.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 16 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Symptoms or signs consistent with spinal column infection
- •MRI findings suggestive of infection
- •Antibiotic treatment for vertebral myelitis
排除标准
- •Patients already treated more than 2 weeks for osteomyelitis in transferring hospital
结局指标
主要结局
Identification of etiology of vertebral osteomyelitis
时间窗: within 6 weeks after the diagnosis of vertebral osteomyelitis
次要结局
- Unfavorable outcomes (death or permanent neurologic deficit)(within 6 months after the diagnosis of vertebral osteomyelitis)