The Prevalence and Characteristics of Adrenal Incidentaloma

Completed

• Conditions: Prevalence; Adrenal Incidentaloma

• Registration Number: NCT04682938
• Lead Sponsor: Chongqing Medical University

Brief Summary

To investige the prevalence, characteristics and prognosis of adrenal incidentalomas in Chinese adults.

Detailed Description

With the development of imaging detection technology and its wide application in clinic, the detection rate of adrenal incidentaloma (AI) has been greatly improved. Most AI are benign and do not have the function of autonomic hormone secretion, but about 20% of them have function and can secrete adrenal hormone autonomously. Studies based on biopsy reports show that the prevalence of AI is about 2%, and the prevalence of AI detected by CT scan is 1% - 4.5%. However, most of these studies are retrospective, and there may be selection bias and other confounding factors. There is no large sample prospective study on the prevalence of AI in the general population. The purpose of this study is to prospectively include patients with adrenal incidentaloma in community physical examination population, and evaluate their function and prognosis. The research results will provide new evidence for standardized diagnosis and treatment of adrenal incidentaloma in the future.

Study Timeline

• Study Start: 2020-11-20
• Study First Submitted: 2020-12-21
• Study First Submitted QC: 2020-12-21
• Study First Posted: 2020-12-24
• Primary Completion: 2021-11-30
• Study Completion: 2021-11-30
• Status Verified: 2022-08
• Last Update Submitted: 2022-08-07
• Last Update Posted: 2022-08-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25356

Inclusion Criteria

·On weekdays, the first 100 individuals, aged 18 to 78 years, taking health checkup in the Community Health Examination Center were invited to take part in the study.

Exclusion Criteria

• with known adrenal diseases;
• with continuous steroids or drug treatment that might influence cortisol secretion ordexamethasone metabolism and could not be stopped
• refuse to participate in the study.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Prevalence and Characteristics of Adrenal Incidentaloma	1 years	To investigate the prevalence and characteristics of Adrenal Incidentaloma in general population in China

Secondary Outcome Measures

Name	Time	Method
Steroid hormones in the function of Adrenal Incidentaloma	1 years	prospectively evaluate potential predictive role of combined detection of multiple steroid hormones in the function of Adrenal Incidentaloma

Trial Locations

Locations (1)

the First Affiliated Hospital of Chongqing Medical University, Chongqing, China; 🇨🇳 Chongqing, Chongqing, China