跳至主要内容
临床试验/NCT04393714
NCT04393714Unknown不适用

Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation. Randomised Controlled Clinical Trial

Cairo University0 个研究点目标入组 8 人开始时间: 2020年10月1日最近更新:
适应症

试验速览

阶段
不适用
入组人数
8
主要终点
Radiographic bone changes

研究概览

简要总结

The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Treatment
盲法
Triple (Participant, Care Provider, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 60 Years(Adult)
性别
All
接受健康志愿者

入选标准

  • Non-restorable teeth
  • medically healthy
  • able to provide informed consent and attend follow-up period

排除标准

  • smokers or alcoholic
  • severe bone loss

结局指标

主要结局

Radiographic bone changes

时间窗: 6 months

width and height losses (quantitative in mm)

次要结局

  • soft tissue healing(Biweekly for 6 weeks)
  • histological analysis(6 months)

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ahmed Mohamed AbdelRaouf Hussein

Principal investigator

Cairo University

相似试验