Demineralized Dentin Graft With Hydrochloric Acid Versus Nitric Acid in Alveolar Ridge Preservation
- Conditions
- Alveolar Bone Loss
- Registration Number
- NCT04393714
- Lead Sponsor
- Cairo University
- Brief Summary
The reduction in alveolar bone dimensions is an inevitable outcome after tooth extraction due to the healing events that results in bone modeling/remodeling. Alveolar ridge preservation is a successful approach that aids in reducing these changes greatly. Various techniques have been employed to achieve that outcome utilizing bone grafts and/or membrane. Dentin graft is a promising type that can overcome many of the limitations facing mainstream grafts. Autogenous source serve the advantage of providing graft with no cross-infection risk or immunogenicity. Moreover, the unique structure of dentin makes it suitable for osteoinduction and osteoconduction that yields favorite bone regeneration outcomes. Demineralization of dentin is essential to release trapped growth factors, expose collagen fibrils and enhance the grafts degradability and replacement by native tissues. Many acids have been investigated for the use in chairside preparation of the dentin graft and hence, clinicians are faced with different choices but little evidence regarding the acid which yield s better outcomes.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 8
- Non-restorable teeth
- medically healthy
- able to provide informed consent and attend follow-up period
- pregnant
- smokers or alcoholic
- severe bone loss
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method Radiographic bone changes 6 months width and height losses (quantitative in mm)
- Secondary Outcome Measures
Name Time Method soft tissue healing Biweekly for 6 weeks rate of wound epitheliallization
histological analysis 6 months Histologic observations (qualitative) and histomorphometric measurements (quantitative in %)
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