Acceptance and Commitment Therapy Versus Cognitive Therapy for the Treatment of Major Depressive Disorder

Not Applicable

Completed

• Conditions: Major Depressive Disorder
• Interventions: Behavioral: Cognitive Therapy; Behavioral: Acceptance and Commitment Therapy

• Registration Number: NCT01517503
• Lead Sponsor: VU University of Amsterdam

Brief Summary

The study will investigate the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with Major Depressive Disorder in routine clinical practice. Furthermore, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism.

Detailed Description

The current study aims at investigating the effectiveness of Cognitive Therapy and Acceptance and Commitment Therapy in a randomized controlled trial among patients with MDD in routine clinical practice. Further, the study will investigate whether each specific treatment approach is mediated by its proposed theoretical mechanism. Patients have to meet diagnostic criteria for nonpsychotic MDD as determined by the Structured Interview for DSM-IV. Each client will receive either Cognitive Therapy or Acceptance and Commitment Therapy that will last between 16 to 20 sessions. Based on previous results, it is expected that both treatment forms will prove beneficial for the patients.

Study Timeline

• Study First Submitted: 2011-11-08
• Study Start: 2011-12
• Study First Submitted QC: 2012-01-20
• Study First Posted: 2012-01-25
• Primary Completion: 2015-08
• Study Completion: 2015-08
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-26
• Last Update Posted: 2019-07-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 82

Inclusion Criteria

1. Meeting DSM-IV criteria for MDD
2. Between the ages of 18 and 65-years-old
3. Having sufficient fluency in Dutch to complete treatment and research protocol

Exclusion Criteria

1. DSM-IV criteria for bipolar disorder (past or present)
2. Psychotic disorders
3. Substance dependence disorders (current or within the past 6 months), or
4. Organic brain syndrome.
5. Borderline or antisocial personality disorder

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Cognitive Therapy (CT)	Cognitive Therapy	Cognitive Therapy (CT)
Acceptance and Commitment Therapy (ACT)	Acceptance and Commitment Therapy	Acceptance and Commitment Therapy (ACT)

Primary Outcome Measures

Name	Time	Method
Hamilton Rating Scale for Depression	pre-treatment, post-treatment	Change from pre-treatment to post-treatment.
QUICK INVENTORY OF DEPRESSIVE SYMPTOMATOLOGY (QIDS-SR)	pre-treatment, post-treatment, 6 and 12 months follow-up	Change from pre-treatment to post-treatment, 6 months follow-up and 12 months follow-up

Secondary Outcome Measures

Name	Time	Method
Eurohis Quality of Life Scale	Pre-, post-treatment, 6 and 12 months follow-up	Change pre-treatment to post-treatment and to follow-up.
Working Alliance Inventory	3. session
Structured Clinical Interview for DSM-IV (Major Depression Module)	Pre-treatment and post-treatment.	Change in diagnosis of Major Depression Disorder from pre-treatment to post-treatment.
Acceptance and Action Questionnaire	Pre-treatment, in-treatment, and 6 and 12 months follow-up.	Change between sessions and to follow-up.
Decentering subscale of the Experiences Questionnaire	Pre-treatment, in-treatment, and 6 and 12 months follow-up.	Change between sessions and to follow-up.
Dysfunctional Attitude Scale-revised	Pre-treatment, in-treatment, and 6 and 12 months follow-up	Change between sessions to follow-up.
Implicit Attitude Test	Pre- and posttreatment	Change pre-treatment to post-treatment
Relationship Scales	Pre-, post-treatment, 12 months follow-up	Change pre-treatment to post-treatment and to follow-up.

Trial Locations

Locations (1)

PsyQ; 🇳🇱 Zaandam, Netherlands