Impact of High Mechanical Index Ultrasound Impulses on Left Ventricular Stroke Volume With Intravenous Microbubbles
- Conditions
- Cardiac Disease
- Registration Number
- NCT05700032
- Lead Sponsor
- University of Nebraska
- Brief Summary
This study will investigate whether applying high mechanical index (MI) impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent (UEA) microbubble infusion will result in subclinical improvement in left ventricle systolic function.
- Detailed Description
The purpose of this study is to investigate whether applying high MI impulses from a diagnostic ultrasound transducer when using ultrasound enhancing agent(UEA) microbubble infusion will result in subclinical improvement in LV systolic function detected by left ventricular outflow tract velocity time integral (LVOT VTI).
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
age 19 years or older
- severe aortic valve stenosis
- pregnant or lactating women
- atrial fibrillation
- very poor image quality despite contrast use.
- unstable cardiac condition such as cardiogenic shock.
- allergy to UEA
- presence of right to left or bidirectional shunts.
- Patients on mechanical circulatory support.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Left Ventricle Outflow Tract (LVOT) First Ventilatory Threshold VTI 10 minutes Left Ventricle Outflow Tract (LVOT) First Ventilatory Threshold VTI
- Secondary Outcome Measures
Name Time Method stroke volume 10 minutes The volume of blood pumped out of the left ventricle of the heart during each systolic cardiac contraction