Rubinstein-Taybi Syndrome: Functional Imaging and Therapeutic Trial
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 发起方
- 入组人数
- 41
- 试验地点
- 2
- 主要终点
- Memory tests (assessing memory learning)
研究概览
简要总结
An exploratory phase 2 therapeutic trial in children from 6 to 21, RTS carriers, randomized to be treated either with sodium valproate with the usual pediatric dosage (30 mg/kg/j), or by placebo for one year.
The investigator would like to include children because they could best profit from it due to their neuronal plasticity as CBP and EP300 take effect through neuronal and synaptic plasticity.
The therapeutic effect of sodium valproate in RTS patients will be assessed thanks to a clinical approach (learning and memory neuropsychological evaluation, fine motor skills assessment by pointing), to a biological approach (histone acetylation functional tests), and to imaging (morphological and functional MRI).
详细描述
Such a multidisciplinary approach has never been presented for this syndrome; it should enable us identifying specific cognitive and motor deficits and their association thanks to imaging markers. Assessing the various aspects of motor skills, i.e. primary (movements, standing at ease position, immobility) and complex motor skills (actions and behaviours, motor aspects of feelings and language expressions) is an integral part of the clinical examination in psychiatrics.
The main interest of a functional capacity analysis is to be used as an index allowing the assessment of the nervous system's global capacities and the study of the connections between cognitive functions and motor skills Main objective: Evaluate long term memory with subtest "point location" - CMS and "image recognition" RBMT A patient is said to be responder if after one year his or her test result increase for one point at least one of the two tests : a increase of one point to "point location" or "image recognition".
Double-blind phase 2 clinical trial, designed as a one-step Fleming design but with a control group. Rubival is a two-parallel group randomized trial:
- a placebo group of 20 patients
- a group of 40 patients taking sodium valproate (HDAC inhibitor) with an oral dosage of 30 mg/kg/jour
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 6 Years 至 21 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Children over 6 and under 21
- •RTS confirmed by a genetic study with a CBP gene or EP300 gene mutation
- •Sufficient cognitive capacities for neuropsychological evaluation
- •Free and informed consent of the parents or guardians
- •Children affiliated to or benefiting of the French social welfare system
排除标准
- •Contraindication to sodium valproate
- •Women of reproductive age without effective contraception means
- •Case history of sodium valproate treatment
- •Monotherapy treatment for epilepsy with Lamictal with a dosage superior to 5 mg/kg/j
- •Family history of severe hepatitis including drug
- •Acute or chronic hepatitis
- •Pregnancy
研究组 & 干预措施
Placebo
Group of 20 patients receiving one year of placebo
干预措施: Placebo (Drug)
Sodium Valproate
Group of 40 patients receiving one year of sodium valproate
干预措施: sodium valproate (Drug)
结局指标
主要结局
Memory tests (assessing memory learning)
时间窗: 1 year
The main outcome measure was to evaluate long term memory with two subtests : * point location, subtest of CMS (children memory scale). The score ranges from 0 to 6 * image recognition, subtest of RBMT (Rivermead Behavioural Memory Test). The score range from 0 to 10. One point for each image recognized A patient is said to be responder if after one year of treatment , his or her test result increase for one point at least one of the two tests
次要结局
- Special brain imaging profile and motor skills (posturology and motor coordination in a visio-manual pointing task)(1 year)
- Cognitive and developmental profile(1 year)
- Histone acetylation profile(1 year)
- Global acetylation level(1 year)
- Acetylation level of selected gene(1 year)
- Measurement of selected gene expression(1 year)