In vivo REsponse evaluation of colorectal liver metastases during systemic therapy using optical SPECTroscopy techniques
- Conditions
- unresectable colorectal liver metastases
- Registration Number
- NL-OMON22669
- Lead Sponsor
- Philips Research
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 22
Inclusion Criteria
1. Patients with unresectable colorectal liver metastases;
2. The liver lesions are safely accessible according to an intervention-radiologist;
Exclusion Criteria
1. Patients with suspected sensitivity to light; e.g. patients who have had photodynamic therapy;
2. Patients with bleeding disorders (such as hemophilia) or bleeding complications from biopsies, dental procedures or surgery;
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The aim of this pilot study is to investigate whether chemotherapy response can be detected with optical spectroscopy (diffuse reflectance and fluorescence spectroscopy) in patients with unresectable colorectal liver metastases receiving first line systemic therapy.<br>
- Secondary Outcome Measures
Name Time Method 1.To compare the accuracy of chemotherapy response using optical spectroscopy with standardized RECIST criteria;<br /><br>2.To correlate spectroscopic measurements with tissue characteristics from biopsies;<br /><br>3.During the measurement procedure, possible improvements to the measurement hardware will be recorded which can provide information for possible alterations of hardware design for improved clinical applicability in the future.