L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement

Not Applicable

Recruiting

• Conditions: Recession, Gingival; Bone Loss in Jaw

• Registration Number: NCT07102758
• Lead Sponsor: Kafrelsheikh University

Brief Summary

comparison between L-prf and connective tissue with dental implant

Detailed Description

comparison between L-PRF and Connective tissue with customized healing abutment regaring soft and hard tissue outcomes with immediate dental implants.

Study Timeline

• Study First Submitted: 2025-07-30
• Study First Submitted QC: 2025-07-30
• Status Verified: 2025-08
• Study Start: 2025-08-05
• Study First Posted: 2025-08-05
• Last Update Submitted: 2025-08-10
• Last Update Posted: 2025-08-14
• Primary Completion: 2026-08-10
• Study Completion: 2027-08-20

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• Intact labial/buccal bone plate
• The presence of non-restorable single-rooted maxillary centrals, canines or premolars.
• Sufficient bone volume.
• Good oral hygiene.
• Nonsmokers.
• Sufficient bone width (≥ 1 mm) in the buccal plate of the remaining bone to place an implant confirmed by cone beam computer tomography (CBCT).

Exclusion Criteria

• Insufficient bone volume.
• Active infection.
• Patients on chemotherapy or radiotherapy.
• Patients who have systemic disorders {uncontrolled diabetes mellitus, autoimmune disease, ...etc},
• Pregnant patients,
• Patients with bone diseases
• Presence of periapical pathology.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Patient-reported pain experience	first 7 days after surgery	Pain experience after surgery is daily measured by the patients using a visual analogue scale (VAS) in the first postoperative 7 days, with Day 0 being the day of the surgery. Before going to sleep, patients will be asked to mark the VAS that best represented the average pain they had experienced during the day.
Pink aesthetic score	before surgery, 3 months and 6 months after surgery	Parameters are : 0,1 and 2.; Mesial papilla : 0 ( Missing ) , 1 ( Incomplete ) and 2 ( Complete ).; Distal Papilla : 0 ( Missing ) , 1 ( Incomplete ) and 2 ( Complete ).; Tissue contour : 0 ( Unnatural) , 1 ( virtually natural ) and 2 ( natural).; Gingival level : 0 ( \>2mm) , 1 ( 1-2mm ) and 2 ( 1 mm).; Alveolar process : 0 ( clearly resorbed ) , 1 ( slightly resorbed ) and 2 ( no difference).; Coloring : 0 ( clear difference ) , 1 ( slight difference ) and 2 ( no difference).; Texture : 0 ( clear difference ) , 1 ( slight difference ) and 2 ( no difference).
crestal bone loss	preoperative and 6 months post operative	distance from implant shoulder to marginal bone

Secondary Outcome Measures

Name	Time	Method
Gingival thickness	pre opearative, 3 and 6 months post operative	1 mm apical to gingival margin in mid buccal
probing pocket depth	preoperative , 3 and 6 months post operative	mid buccal , mesio buccal , disto buccal and mid palatal
keratinized tissue width	preoperative , 3 and 6 months post operative	in mid buccal, from gingival margin to mucogingival junction

Trial Locations

Locations (1)

Kafrelsheikh University; 🇪🇬 Kafr Ash Shaykh, Kafrelsheikh, Egypt