Nottingham Osteoarthritis Biomarker Study 2011

Completed

• Conditions: Osteoarthritis

• Registration Number: NCT01495455
• Lead Sponsor: University of Nottingham

Brief Summary

Osteoarthritis is by far the most common joint condition and the single largest cause of disability in the older population. The investigators still have a poor understanding of the nature of osteoarthritis and factors that influence its development and progression. Identification of biochemical markers that relate to cartilage loss, bony overgrowth and other features that occur with osteoarthritis will advance our understanding. Over the last 5 years analytical methods have developed to measure a range of different biomarkers. This pilot study will use these analytical methods to measure biomarker levels in joint fluid, urine and blood of 50 participants with Osteoarthritis (OA) and 50 healthy volunteers.

This study will provide novel pilot data on the changes in the composition of the synovial fluid, urine and blood in patients with OA. Apart from being a key target site for OA, the knee is a suitable joint for study because of its accessibility to clinical assessment, joint aspiration and imaging.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2011-11-30
• Study First Submitted QC: 2011-12-15
• Study First Posted: 2011-12-20
• Study Start: 2012-02
• Status Verified: 2013-01
• Primary Completion: 2013-01
• Study Completion: 2013-01
• Last Update Submitted: 2013-01-29
• Last Update Posted: 2013-01-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

All participants:

• Be able to provide written informed consent
• Aged 30 and over

Knee OA patients:

• Radiographic signs of OA - that is definite joint space narrowing plus osteophyte in at least one compartment of the knee

Normal controls:

• No knee pain
• No clinical or radiographic changes of knee OA

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Difference in the levels of pro-inflammatory and anti-inflammatory lipids mediators between individuals with knee osteoarthritis and those with normal knees.	within 6 months of recruitment of last participant

Trial Locations

Locations (1)

Academic Rheumatology, University of Nottingham; 🇬🇧 Nottingham, United Kingdom