Evolution of the Lymphocyte Phenotype in Patients with Infection in Intensive Care Unit

Not Applicable

Recruiting

• Conditions: Patients Undergoing Esophagectomy; Patients with Severe Polytrauma; Patients with Severe Neurological Lesion; Patients with Abdominal Infection
• Interventions: Procedure: Lymphocyte Phenotyping Procedure

• Registration Number: NCT06415474
• Lead Sponsor: University Hospital, Brest

Brief Summary

Patients admitted for polytrauma, severe neurological injury, post-operative monitoring or sepsis/septic shock present with significant inflammation, leading to immunoparalysis, which is responsible for infection, particularly prolonged infection. A study of their lymphocyte phenotype over time could help explore the phenomenon of immunoparalysis.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2024-04-26
• Study First Submitted QC: 2024-05-14
• Study First Posted: 2024-05-16
• Study Start: 2024-10-03
• Status Verified: 2025-02
• Last Update Submitted: 2025-02-03
• Last Update Posted: 2025-02-05
• Primary Completion: 2026-10-03
• Study Completion: 2026-11-03

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Phenotyping arm	Lymphocyte Phenotyping Procedure	There is only one arm in the study. All patients (i.e. our 4 target populations) will undergo the same phenotyping procedure.

Primary Outcome Measures

Name	Time	Method
Lymphocytes numbers variation	At the midpoint of the prescribed antibiotic course	- Numbers of various lymphocytes (LT, LB, NK and their subclasses) at half duration of infection's treatment according to reason for admission (postoperative vs sepsis/septic shock vs polytrauma vs neurological injury)
Lymphocytes percentages variation	At the midpoint of the prescribed antibiotic course	- Percentage rate of various lymphocytes (LT, LB, NK and their subclasses) at half duration of infection's treatment according to reason for admission (postoperative vs sepsis/septic shock vs polytrauma vs neurological injury)

Secondary Outcome Measures

Name	Time	Method
Lymphocytes numbers variation in case of infection	Immediately following resolution of infection	Numbers rate in various lymphocytes (LT, LB, NK and their subclasses) at resolution of infection
Lymphocytes percentages variation in case of infection	Immediately following resolution of infection	Percentage rate in various lymphocytes (LT, LB, NK and their subclasses) at resolution of infection

Trial Locations

Locations (1)

CHU de Brest; 🇫🇷 Brest, France