Propofol + Remifentanil vs. Propofol + Dexmedetomidine in Adolescent Idiopathic Scoliosis Patients Having Spine Surgery

Phase 2

Recruiting

• Conditions: Adolescent Idiopathic Scoliosis; Multimodal Analgesia; Opioid Induced Hyperalgesia; Remifentanil; Dexmedetomidine; Posterior Spinal Fusion

• Registration Number: NCT06096181
• Lead Sponsor: Cedars-Sinai Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2023-10-16
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Age 12-18 years old<br><br> - American Society of Anesthesiology Physical Status Classification (ASA Class) 1 and<br> 2<br><br> - Have diagnosis of Adolescent Idiopathic Scoliosis<br><br> - Undergoing Posterior Spinal Fusion with instrumentation for scoliosis correction<br><br> - Matched on age, sex, and the number of vertebral levels fused<br><br>Exclusion Criteria:<br><br> - Neuromuscular scoliosis<br><br> - Allergy to any of the multi-modal analgesia regimen drugs<br><br> - Use of serotonergic drugs, monoamine oxidase inhibitors (MAOI), mixed<br> agonist/antagonist opioid analgesics

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total opioid consumption (IV and PO in MME) on POD# 0 and 1

Secondary Outcome Measures

Name	Time	Method
Average VAS Pain score on POD# 0 and 1;Time from skin closure to participant being able to move their feet on command (mins);Time from skin closure to Extubation