Predictive Score for Neonatal Mortality for Women With Premature Rupture of Membranes Between 22 and 28 Weeks of Gestation
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Perinatal Mortality
- Sponsor
- Centre Hospitalier Universitaire, Amiens
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- The purpose was to determine which antepartum criteria were efficient to predict neonatal death, in order to create a predictive prognostic antenatal index of mortality.
- Last Updated
- 8 years ago
Overview
Brief Summary
Pretern premature rupture of the membranes (PPROM) remains the leading cause of preterm deliveries and neonatal mortality and morbidity. PPROM is defined as rupture of the fetal membranes prior to 37 weeks' gestation. PPROM complicates 2-4% of all pregnancies and accounts for approximately 30 % of preterm births.
The etiology of PPROM remains elusive. PPROM is one of the main causes of prematurity and its complications, such as newborn respiratory distress syndrome, neonatal sepsis, necrotizing enterocolitis, intraventricular hemorrhage, perventricular leucomalacia, varying degrees of lung hypoplasia and bronchopulmonary dysplasia. All these factors contribute greatly to an increase in neonatal morbidity and mortality Management of PPROM followed actual guidelines. Conservative management to prolong a pregnancy is a classical approach to treat PPROM before 34 weeks' gestation in association with antibiotic therapy and corticosteroids.
Maternal and neonatal data were collected from maternal and newborns medical records.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Women with PPROM between 22 weeks and 27 weeks and 6 days are eligible for this study
Exclusion Criteria
- •Therapeutic abortion / terminaison of pregnancy
- •Intra uterine demise
- •active labor with cervical dilatation of 3 cm with regular contractions.
- •Triplet pregnancies
Outcomes
Primary Outcomes
The purpose was to determine which antepartum criteria were efficient to predict neonatal death, in order to create a predictive prognostic antenatal index of mortality.
Time Frame: 1 day