Development of a Noninvasive Method of Evaluation of Pulmonary Inflammation in the Condensates of Exhaled Air

Terminated

• Conditions: Condensate of Exhaled Air; Mucoviscidosis; Bronchopulmonary Ignition; Asthma

• Registration Number: NCT00356629
• Lead Sponsor: University Hospital, Tours

Brief Summary

The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD, asthma, tobacco exposure. Three proteases will be analyzed, i.e. elastase, proteinase 3 and cathepsin G. Results in the condensates will be compared to those obtained in sputum.

Detailed Description

5 groups of 20 individuals each: group 1 CF, group 2 COPD, group 3 asthma, group 4 tobacco exposure, group 5 control subjects.

Collection of exhaled condensates in all subjects and of sputum in subjects belonging to groups 1 and 2.

Clinical examination and PFTs in all patients.

Study Timeline

• Study Start: 2006-07
• Study First Submitted: 2006-07-25
• Study First Submitted QC: 2006-07-25
• Study First Posted: 2006-07-26
• Study Completion: 2008-07
• Status Verified: 2008-11
• Last Update Submitted: 2008-11-13
• Last Update Posted: 2008-11-14

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

Not provided

Exclusion Criteria

• acute exacerbation of the disease during the last 2 weeks
• IV or oral steroids or antibiotics during the last 2 weeks
• hospitalization during the last 2 weeks
• colonization by S aureus methicillin resistant and/or Burkholderia cepacia

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Service de Pneumologie et EFR CHRU Tours; 🇫🇷 Tours, France