NCT00356629
Terminated
Not Applicable
Development of a Noninvasive Method of Evaluation of the Pulmonary Inflammation in the Condensates of Exhaled Air
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Bronchopulmonary Ignition
- Sponsor
- University Hospital, Tours
- Enrollment
- 100
- Locations
- 1
- Status
- Terminated
- Last Updated
- 17 years ago
Overview
Brief Summary
The aim of the study is identify biological parameters reflecting proteolytic activity in the exhaled condenstaes which might be useful to follow up pulmonary inflammation in various conditions including cystic fibrosis, COPD, asthma, tobacco exposure. Three proteases will be analyzed, i.e. elastase, proteinase 3 and cathepsin G. Results in the condensates will be compared to those obtained in sputum.
Detailed Description
5 groups of 20 individuals each: group 1 CF, group 2 COPD, group 3 asthma, group 4 tobacco exposure, group 5 control subjects. Collection of exhaled condensates in all subjects and of sputum in subjects belonging to groups 1 and 2. Clinical examination and PFTs in all patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •acute exacerbation of the disease during the last 2 weeks
- •IV or oral steroids or antibiotics during the last 2 weeks
- •hospitalization during the last 2 weeks
- •colonization by S aureus methicillin resistant and/or Burkholderia cepacia
Outcomes
Primary Outcomes
Not specified
Study Sites (1)
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