To determine if 0.2% topical Nifedipine has better healing rates than 0.2% topical Glyceryl Trinitrate in the treatment of Chronic Anal Fissures
Not Applicable
- Conditions
- Digestive SystemChronic Anal Fissure
- Registration Number
- PACTR201304000524290
- Lead Sponsor
- Board of Postgraduate Medical Education, Aga Khan University Hospital
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 66
Inclusion Criteria
1. Age : 18 years or older
2. History of anal pain on defecation for at least 6 weeks
±
3. Presence of any 1 of the following:
-Sentinel pile
-Hypertrophied apical papilla or
-Visible fibres of IAS
Exclusion Criteria
1.Fissures not consistent with above diagnostic criteria
2.Previous surgery for anal fissure
3.Fissures secondary to other diseases e.g. Crohn¿s disease, ulcerative colitis, malignancies, tuberculosis etc.
4.Associated complications warranting surgery (abscess, fistula etc)
5.Coexistent medical conditions using calcium channel blocker and oral, sublingual or transdermal nitrates
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The overall healing rate of Nifedipine vs GTN-treated patients with chronic anal fissure
- Secondary Outcome Measures
Name Time Method What proportion of participants have epithelialization or formation of a scar by 2, 4, 6 and 8 weeks;The resolution of pain