To determine if 0.2% topical Nifedipine has better healing rates than 0.2% topical Glyceryl Trinitrate in the treatment of Chronic Anal Fissures

Not Applicable

Completed

• Conditions: Digestive System; Chronic Anal Fissure

• Registration Number: PACTR201304000524290
• Lead Sponsor: Board of Postgraduate Medical Education, Aga Khan University Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2013-03-18
• Last Update Posted: 2023-05-29

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

1. Age : 18 years or older

2. History of anal pain on defecation for at least 6 weeks
±
3. Presence of any 1 of the following:
-Sentinel pile
-Hypertrophied apical papilla or
-Visible fibres of IAS

Exclusion Criteria

1.Fissures not consistent with above diagnostic criteria
2.Previous surgery for anal fissure
3.Fissures secondary to other diseases e.g. Crohn¿s disease, ulcerative colitis, malignancies, tuberculosis etc.
4.Associated complications warranting surgery (abscess, fistula etc)
5.Coexistent medical conditions using calcium channel blocker and oral, sublingual or transdermal nitrates

Study & Design

• Study Type: Interventional
• Study Design: Not specified