Increased CRP Concentrations in Patients Admitted to the Emergency Department With Troponin Elevation Aids to Rule Out Coronary Ischemia
- Conditions
- Myocardial Ischemia
- Interventions
- Diagnostic Test: Diagnosis of Myocardial Ischemia
- Registration Number
- NCT04522583
- Lead Sponsor
- Hillel Yaffe Medical Center
- Brief Summary
The investigators hypothesized that the CRP/troponin ratio measured in patients presenting to the ED with elevated troponin levels could differentiate between patients with cardiac ischemia and those who present due to a systemic inflammatory or infectious disease. The aim of the study was to determine the necessary CRP/troponin ratio required to rule out cardiac ischemia in a large ED population and determine its impact on long-term prognosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 15000
Inclusion Criteria
- All patients admitted to the ED in the period 2016-2019 with cTn level higher than the 99th percentile of cTn concentration in the normal population (>0.014 nanogram/milliliter).
Exclusion Criteria
- None
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Troponin-positive ED patients Diagnosis of Myocardial Ischemia All patients admitted to the ED at the Hillel Yaffe Medical Center in Hadera, Israel, in the period 2016-2019 with cTn level higher than the 99th percentile of cTn concentration in the normal population (\>0.014 nanogram/milliliter).
- Primary Outcome Measures
Name Time Method Accuracy of the CRP/Troponin ratio Within 6 months The accuracy of the CRP/Troponin ratio in ruling out of myocardial ischemia according to the diagnosis of ischemia/coronary intervention at discharge analyzed by standard statistical measures
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hille Yaffe Medical Center
🇮🇱Hadera, Israel